Aggression, Hostility, and Irritability in Children at Risk for Bipolar Disorder

Overview

Journal Bipolar Disord

Specialty Psychiatry

Date 2007 Aug 8

PMID 17680920

Citations 11

Authors

Tiffany R Farchione

Boris Birmaher

David Axelson

Cathy Kalas

Kelly Monk

Mary Ehmann

Satish Iyengar

David Kupfer

David Brent

Affiliations

Soon will be listed here.

Abstract

Objectives: To assess aggression, irritability and hostility in children at risk for bipolar disorder (BP).

Methods: Using the parent and the child versions of the Children's Hostility Inventory (CHI), we assessed aggression, hostility, and irritability in 300 offspring aged 6-18 years old of BP parents and 169 children of community controls.

Results: Children of BP parents have significantly higher scores on the total CHI and its subscales than do children of control parents. After adjusting for demographic variables, both parents' non-BP psychopathology, child psychopathology, and within-family correlations, three factors remain significant: total CHI by parent rating, irritability subscale by parent rating, and irritability by child self-report. The hostility subscale by parent rating became a trend.

Conclusions: Children of BP parents score higher on ratings of hostility and irritability than children of community control parents, independent of child psychopathology and non-BP parental psychopathology. Follow-up of these children to evaluate whether these symptoms are markers for the development of BP or mood disorders is warranted.

Citing Articles

Behavioral self-regulation in pediatric bipolar disorder and healthy offspring of bipolar patients.

Rocca C, Caetano S, Belizario G, Kleinman A, de Abreu L, Lafer B Braz J Psychiatry. 2023; 45(3):236-241.

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Offspring of mothers with bipolar disorder: a systematic review considering personality features.

Bastos R, Campos L, Faria-Schutzer D, Brito M, da Silva D, Dos Santos-Junior A Braz J Psychiatry. 2022; 44(1):94-102.

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Aggression Protects Against the Onset of Major Depressive Episodes in Individuals With Bipolar Spectrum Disorder.

Ng T, Freed R, Titone M, Stange J, Weiss R, Abramson L Behav Ther. 2017; 48(3):311-321.

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Behavior and emotion modulation deficits in preschoolers at risk for bipolar disorder.

Tseng W, Guyer A, Briggs-Gowan M, Axelson D, Birmaher B, Egger H Depress Anxiety. 2015; 32(5):325-34.

PMID: 25691090 PMC: 4409452. DOI: 10.1002/da.22342.

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