Accommodation of Grafts: Implications for Health and Disease

Overview

Journal Hum Immunol

Specialty Allergy & Immunology

Date 2007 Aug 7

PMID 17678718

Citations 23

Authors

Amy H Tang

Jeffrey L Platt

Affiliations

Soon will be listed here.

Abstract

Accommodation refers to the acquired resistance of a graft to immune-mediated injury. It is typically observed after antibodies that would cause rejection of a graft are removed from a recipient and then later return. In addition to being induced in this manner, accommodation can occur spontaneously, without depleting antibodies. Indeed, we postulate spontaneous accommodation may be the most common outcome of clinical organ transplantation. The paper reviews the current understanding of accommodation, emphasizing recent advances and important questions. Among the recent advances are the discoveries of potentially broader relevance of accommodation for biology and immunology and pathways by which accommodation may be achieved. To investigate these pathways and to understand how accommodation begins and how it evolves, clinical organ transplants might offer a useful and incisive model.

Citing Articles

TNFRSF13B in B cell responses to organ transplantation.

Cascalho M, Platt J Hum Immunol. 2022; 84(1):27-33.

PMID: 36333165 PMC: 10429825. DOI: 10.1016/j.humimm.2022.09.006.

Accommodation in allogeneic and xenogeneic organ transplantation: Prevalence, impact, and implications for monitoring and for therapeutics.

Platt J, Cascalho M Hum Immunol. 2022; 84(1):5-17.

PMID: 36244871 PMC: 10339678. DOI: 10.1016/j.humimm.2022.08.001.

Endothelial Dysfunction after Hematopoietic Stem Cell Transplantation: A Review Based on Physiopathology.

Milone G, Bellofiore C, Leotta S, Milone G, Cupri A, Duminuco A J Clin Med. 2022; 11(3).

PMID: 35160072 PMC: 8837122. DOI: 10.3390/jcm11030623.

Detecting donor-specific antibodies: the importance of sorting the wheat from the chaff.

McCaughan J, Xu Q, Tinckam K Hepatobiliary Surg Nutr. 2019; 8(1):37-52.

PMID: 30881964 PMC: 6383008. DOI: 10.21037/hbsn.2019.01.01.

Accommodation and related conditions in vascularized composite allografts.

Platt J, Kaufman C, de Mattos Barbosa M, Cascalho M Curr Opin Organ Transplant. 2017; 22(5):470-476.

PMID: 28682798 PMC: 5648361. DOI: 10.1097/MOT.0000000000000446.

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