[Toxic Epidermal Necrolysis Induced by Phenytoin and Whole Brain Radiotherapy]

Overview

Journal Actas Dermosifiliogr

Specialty Dermatology

Date 2007 Aug 3

PMID 17669303

Citations 5

Authors

F A Fernandez

E Pintor

R Quesada

F J Garces

Affiliations

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Abstract

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin. Some authors have pointed out an increased risk of TEN/SJS when phenytoin is associated with whole brain radiotherapy. We report a patient diagnosed with breast adenocarcinoma and brain metastases that was on treatment with phenytoin and, shortly after receiving whole brain radiotherapy, developed toxic epidermal necrolysis.

Citing Articles

Phenytoin-induced toxic epidermal necrolysis: Review and recommendations.

Al-Quteimat O J Pharmacol Pharmacother. 2016; 7(3):127-32.

PMID: 27651708 PMC: 5020771. DOI: 10.4103/0976-500X.189662.

Toxic Epidermal Necrolysis Following Phenytoin and Cranial Irradiation.

Riyaz N, Sasidharanpillai S, Rahima S, Kavitha M Indian J Dermatol. 2015; 60(4):424.

PMID: 26288458 PMC: 4533589. DOI: 10.4103/0019-5154.160551.

Toxic epidermal necrolysis in hemodialysis patient.

Mateti U, Nagaraju S, Bairy M, Prabhu Attur R, Nagappa A, Rao A Adv Biomed Res. 2015; 4:63.

PMID: 25821763 PMC: 4374200. DOI: 10.4103/2277-9175.152119.

Phenytoin- and cranial radiotherapy-induced toxic epidermal necrolysis treated with combination therapy: systemic steroid and intravenous immunoglobulin.

Fidan E, Fidan M, Ozdemir F, Kavgaci H, Aydin F Med Oncol. 2011; 29(2):686-9.

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Rash in four patients with brain tumor-related epilepsy in monotherapy with oxcarbazepine, during radiotherapy.

Maschio M, Dinapoli L, Vidiri A, Muti P J Neurol. 2010; 257(11):1939-40.

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