Bidirectional Long Short-Term Memory Networks for Predicting the Subcellular Localization of Eukaryotic Proteins

An algorithm called Bidirectional Long Short-Term Memory Networks (BLSTM) for processing sequential data is introduced. This supervised learning method trains a special recurrent neural network to use very long ranged symmetric sequence context using a combination of nonlinear processing elements and linear feedback loops for storing long-range context. The algorithm is applied to the sequence-based prediction of protein localization and predicts 93.3 percent novel non-plant proteins and 88.4 percent novel plant proteins correctly, which is an improvement over feedforward and standard recurrent networks solving the same problem. The BLSTM system is available as a web-service (http://www.stepc.gr/~synaptic/blstm.html).