Hepatoma with Cardiac Metastasis: an Advanced Cancer Requiring Advanced Treatment

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2007 Jul 31

PMID 17659700

Citations 4

Authors

Yu-Sheng Lin

Shih-Ming Jung

Feng-Chun Tsai

Chun-Nan Yeh

Tzu-Fang Shiu

Hsueh-Hua Wu

Pyng-Jing Lin

Pao-Hsien Chu

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the clinical and pathologic findings, and to discuss the pathophysiology of hepatocellular carcinoma with cardiac metastasis.

Methods: Eight hepatoma patients with cardiac metastasis, who were treated by surgical excision from 1993 to 2006, were retrospectively studied. Detailed clinical parameters were analyzed.

Results: Of those eight patients, two (25%) were women and six (75%) were men, with the mean age of 50 years (range, 40-70 years). The presentations included: asymptomatic (75%), heart failure (25%), and pulmonary embolism (12.5%). All lesions involved the right atrium, and extended to the lung (12.5%), inferior vena cava (25%), and left atrium (12.5%). The level of tumor marker, alpha-fetal protein, was not correlated with the severity of metastasis or disease prognosis. Moreover, the availably estimated doubling time was less than 3 mo. The pathological findings included variable hemorrhage and necrosis. The survival time following surgery also varied from one month to more than 30 mo.

Conclusion: Hepatoma metastasis to the heart was detected in all eight patients. This study demonstrates that surgery might help the outcome in such cases.

Citing Articles

Cardiac Hepatoma: An Unlikely Cause of Malignant Cardiac Metastatic Disease.

Vicenty-Rivera S, Molina-Lopez V, Rodriguez A Cureus. 2024; 16(9):e69202.

PMID: 39345809 PMC: 11436280. DOI: 10.7759/cureus.69202.

Metastasis from Hepatocellular Carcinoma Masquerading as a Jugular Paraganglioma.

Chaudhary D, Patkar S, Shrikhande S, Goel M J Gastrointest Cancer. 2017; 49(4):517-519.

PMID: 28374273 DOI: 10.1007/s12029-017-9943-8.

Isolated nasopharyngeal metastasis from hepatocellular carcinoma.

Kattepur A, Patil D, Krishnamoorthy N, Srinivas K, Swamy S, Amarendra S Int J Surg Case Rep. 2014; 5(3):115-7.

PMID: 24509427 PMC: 3955226. DOI: 10.1016/j.ijscr.2013.12.009.

A case of left atrial metastasis from hepatocellular carcinoma: life-saving palliative resection using cardiopulmonary bypass.

Seo J, Kim J, Jeong D, Chung W, Kim S, Kim M Korean Circ J. 2011; 41(9):542-5.

PMID: 22022330 PMC: 3193046. DOI: 10.4070/kcj.2011.41.9.542.

References

Uemura M, Sasaki Y, Yamada T, Eguchi H, Ohigashi H, Doki Y . Surgery for hepatocellular carcinoma with tumor thrombus extending into the right atrium: report of a successful resection without the use of cardiopulmonary bypass. Hepatogastroenterology. 2004; 51(59):1259-62. View

Chu P, Jung S, Wu H, Chien L, Hsueh C, Chu J . Apoptosis in primary cardiac tumours. Int J Clin Pract. 2004; 58(6):564-7. DOI: 10.1111/j.1368-5031.2004.00118.x. View

Ebara M, OHTO M, Shinagawa T, Sugiura N, Kimura K, Matsutani S . Natural history of minute hepatocellular carcinoma smaller than three centimeters complicating cirrhosis. A study in 22 patients. Gastroenterology. 1986; 90(2):289-98. DOI: 10.1016/0016-5085(86)90923-6. View

Parkin D, Pisani P, Ferlay J . Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer. 1993; 54(4):594-606. DOI: 10.1002/ijc.2910540413. View

Chu P, Jung S, Yeh T, Lin H, Chu J . MUC1, MUC2 and MUC5AC expressions in cardiac myxoma. Virchows Arch. 2004; 446(1):52-5. DOI: 10.1007/s00428-004-1147-5. View

Miyazawa M, Torii T, Asano H, Yamada M, Toshimitsu Y, Shinozuka N . Does a surgery for hepatocellular carcinoma with tumor thrombus highly occupying in the right atrium have significance? A case report and review of the literature. Hepatogastroenterology. 2005; 52(61):212-6. View

Chu P, Jung S, Lin H, Yeh C, Wu H, Shiu T . Caspase-3-dependent apoptosis in cardiac myxoma: not associated with human papillomavirus or Epstein-Barr virus. Mod Pathol. 2005; 18(6):822-7. DOI: 10.1038/modpathol.3800364. View

Taouli B, Goh J, Lu Y, Qayyum A, Yeh B, Merriman R . Growth rate of hepatocellular carcinoma: evaluation with serial computed tomography or magnetic resonance imaging. J Comput Assist Tomogr. 2005; 29(4):425-9. DOI: 10.1097/01.rct.0000164036.85327.05. View

Nakajima J, Tanaka M, Matsumoto J, Takeuchi E, Fukami T, Takamoto S . Appraisal of surgical treatment for pulmonary metastasis from hepatocellular carcinoma. World J Surg. 2005; 29(6):715-8. DOI: 10.1007/s00268-005-7687-2. View

10.

Natsuizaka M, Omura T, Akaike T, Kuwata Y, Yamazaki K, Sato T . Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol. 2005; 20(11):1781-7. DOI: 10.1111/j.1440-1746.2005.03919.x. View

11.

OByrne K, Dalgleish A, Browning M, Steward W, Harris A . The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease. Eur J Cancer. 2000; 36(2):151-69. DOI: 10.1016/s0959-8049(99)00241-5. View

12.

Chu P, Chiang C, Hsu L, Lin K, Cheng N, Kuo C . Low prevalence of coronary arterial disease in Chinese adults with mitral stenosis. Chang Gung Med J. 2001; 24(2):97-102. View

13.

Baca-Lopez F, Ramirez-Arias E, Rayas-Gomez A, Bernal-Ruiz E, Saturno-Chiu G . Hepatocellular carcinoma with invasion into right cardiac cavities: report of a case and literature review. J Am Soc Echocardiogr. 2004; 17(2):192-4. DOI: 10.1016/j.echo.2003.10.007. View

14.

Chu P, Jung S, Yeh C, Yeh T, Wang C . Mucin gene expression in cardiac myxoma. Int J Clin Pract. 2004; 58(3):306-9. DOI: 10.1111/j.1368-5031.2004.00042.x. View

15.

Qin L, Tang Z . Recent progress in predictive biomarkers for metastatic recurrence of human hepatocellular carcinoma: a review of the literature. J Cancer Res Clin Oncol. 2004; 130(9):497-513. DOI: 10.1007/s00432-004-0572-9. View

16.

Tsujimoto M, Aozasa K, Nakajima Y, Kariya M . Hepatocellular carcinoma with sarcomatous proliferation showing an unusual and wide-spread metastasis. Acta Pathol Jpn. 1984; 34(4):839-45. DOI: 10.1111/j.1440-1827.1984.tb07612.x. View