CD8 T Cell Dysfunction During Chronic Viral Infection

Overview

Journal Curr Opin Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2007 Jul 28

PMID 17656078

Citations 212

Authors

Haina Shin

E John Wherry

Affiliations

Soon will be listed here.

Abstract

Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.

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