The Blood Platelet Proteome is Changed in UREMIC Patients
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Comparative analysis of the protein profile of blood platelets isolated from nondialyzed and hemodialyzed uremic patients and healthy controls has been performed. These preliminary results indicate markedly changed expression of several proteins in blood platelets from both groups of patients compared with controls, with dramatic changes in hemodialyzed patients in the over-expression of low molecular peptides with a very wide range of pI values.
Cremer S, Catalfamo J, Goggs R, Seemann S, Kristensen A, Szklanna P Res Pract Thromb Haemost. 2021; 5(1):55-68.
PMID: 33537530 PMC: 7845059. DOI: 10.1002/rth2.12450.
Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS).
Cremer S, Catalfamo J, Goggs R, Seemann S, Kristensen A, Brooks M PLoS One. 2019; 14(11):e0224891.
PMID: 31721811 PMC: 6853320. DOI: 10.1371/journal.pone.0224891.
Alteration of the platelet transcriptome in chronic kidney disease.
Ple H, Maltais M, Corduan A, Rousseau G, Madore F, Provost P Thromb Haemost. 2012; 108(4):605-15.
PMID: 22836280 PMC: 3557501. DOI: 10.1160/TH12-03-0153.
OConnor R, Cryan L, Wynne K, de Stefani A, Fitzgerald D, OBrien C J Biomed Biotechnol. 2010; 2010:107859.
PMID: 20368775 PMC: 2846341. DOI: 10.1155/2010/107859.