Automated Liquid-liquid Extraction Workstation for Library Synthesis and Its Use in the Parallel and Chromatography-free Synthesis of 2-alkyl-3-alkyl-4-(3H)-quinazolinones

An automated liquid-liquid extraction workstation has been developed. This module processes up to 96 samples in an automated and parallel mode avoiding the time-consuming and intensive sample manipulation during the workup process. To validate the workstation, a highly automated and chromatography-free synthesis of differentially substituted quinazolin-4(3H)-ones with two diversity points has been carried out using isatoic anhydride as starting material.