Differential Role of Kinin B1 and B2 Receptors in Ischemia-induced Apoptosis and Ventricular Remodeling

Overview

Journal Peptides

Specialty Biochemistry

Date 2007 Jul 24

PMID 17644219

Citations 17

Authors

Hang Yin

Julie Chao

Michael Bader

Lee Chao

Affiliations

Soon will be listed here.

Abstract

We investigated the role of kinin receptors in cardiac remodeling after ischemia/reperfusion (I/R). Bradykinin injection improved cardiac contractility, diastolic function, reduced infarct size and prevented left ventricular thinning after I/R, whereas des-Arg(9)-BK injection had no protective effects. Bradykinin, but not des-Arg(9)-BK, reduced cardiomyocyte apoptosis and increased Akt and GSK-3beta phosphorylation. Furthermore, myocardial infarct size was similar between wild type and B2 knockout mice after I/R, but significantly reduced in kinin B1 receptor knockout mice. These results indicate that the kinin B2 receptor, but not the B1 receptor, protects against I/R-induced cardiac dysfunction by inhibiting apoptosis and limiting ventricular remodeling.

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References

Liu X, Lukasova M, Zubakova R, Lewicka S, Hilgenfeldt U . Kallidin-like peptide mediates the cardioprotective effect of the ACE inhibitor captopril against ischaemic reperfusion injury of rat heart. Br J Pharmacol. 2006; 148(6):825-32. PMC: 1617066. DOI: 10.1038/sj.bjp.0706799. View

Schoemaker R, van Heijningen C . Bradykinin mediates cardiac preconditioning at a distance. Am J Physiol Heart Circ Physiol. 2000; 278(5):H1571-6. DOI: 10.1152/ajpheart.2000.278.5.H1571. View

Kositprapa C, Ockaili R, Kukreja R . Bradykinin B2 receptor is involved in the late phase of preconditioning in rabbit heart. J Mol Cell Cardiol. 2001; 33(7):1355-62. DOI: 10.1006/jmcc.2000.1396. View

Lagneux C, Bader M, Pesquero J, Demenge P, Ribuot C . Detrimental implication of B1 receptors in myocardial ischemia: evidence from pharmacological blockade and gene knockout mice. Int Immunopharmacol. 2002; 2(6):815-22. DOI: 10.1016/s1567-5769(02)00022-x. View

Sandmann S, Kaschina E, Blume A, Kruse M, Unger T . Bradykinin B1 and B2 receptors differentially regulate cardiac Na+-H+ exchanger, Na+-Ca2+ exchanger and Na+-HCO3- symporter. Eur J Pharmacol. 2002; 458(1-2):3-16. DOI: 10.1016/s0014-2999(02)02656-0. View

Ito H, Hayashi I, Izumi T, Majima M . Bradykinin inhibits development of myocardial infarction through B2 receptor signalling by increment of regional blood flow around the ischaemic lesions in rats. Br J Pharmacol. 2003; 138(1):225-33. PMC: 1573639. DOI: 10.1038/sj.bjp.0705013. View

Bell R, Yellon D . Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS. J Mol Cell Cardiol. 2003; 35(2):185-93. DOI: 10.1016/s0022-2828(02)00310-3. View

Oldenburg O, Qin Q, Krieg T, Yang X, Philipp S, Critz S . Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection. Am J Physiol Heart Circ Physiol. 2003; 286(1):H468-76. DOI: 10.1152/ajpheart.00360.2003. View

Souza D, Lomez E, Pinho V, Bosco Pesquero J, Bader M, Pesquero J . Role of bradykinin B2 and B1 receptors in the local, remote, and systemic inflammatory responses that follow intestinal ischemia and reperfusion injury. J Immunol. 2004; 172(4):2542-8. DOI: 10.4049/jimmunol.172.4.2542. View

10.

Tschope C, Spillmann F, Altmann C, Koch M, Westermann D, Dhayat N . The bradykinin B1 receptor contributes to the cardioprotective effects of AT1 blockade after experimental myocardial infarction. Cardiovasc Res. 2004; 61(3):559-69. DOI: 10.1016/j.cardiores.2003.10.018. View

11.

Yang X, Krieg T, Cui L, Downey J, Cohen M . NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO. J Mol Cell Cardiol. 2004; 36(3):411-21. DOI: 10.1016/j.yjmcc.2003.12.008. View

12.

Goto M, Liu Y, Yang X, Ardell J, Cohen M, Downey J . Role of bradykinin in protection of ischemic preconditioning in rabbit hearts. Circ Res. 1995; 77(3):611-21. DOI: 10.1161/01.res.77.3.611. View

13.

Regoli D, Nsa Allogho S, Rizzi A, Gobeil F . Bradykinin receptors and their antagonists. Eur J Pharmacol. 1998; 348(1):1-10. DOI: 10.1016/s0014-2999(98)00165-4. View

14.

Hu K, Gaudron P, Anders H, Weidemann F, Turschner O, Nahrendorf M . Chronic effects of early started angiotensin converting enzyme inhibition and angiotensin AT1-receptor subtype blockade in rats with myocardial infarction: role of bradykinin. Cardiovasc Res. 1998; 39(2):401-12. DOI: 10.1016/s0008-6363(98)00090-x. View

15.

Zhu P, Zaugg C, Hornstein P, Allegrini P, Buser P . Bradykinin-dependent cardioprotective effects of losartan against ischemia and reperfusion in rat hearts. J Cardiovasc Pharmacol. 1999; 33(5):785-90. DOI: 10.1097/00005344-199905000-00016. View

16.

Krieg T, Qin Q, Philipp S, Alexeyev M, Cohen M, Downey J . Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS. Am J Physiol Heart Circ Physiol. 2004; 287(6):H2606-11. DOI: 10.1152/ajpheart.00600.2004. View

17.

Yin H, Chao L, Chao J . Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathways. J Biol Chem. 2004; 280(9):8022-30. DOI: 10.1074/jbc.M407179200. View

18.

Xu J, Carretero O, Sun Y, Shesely E, Rhaleb N, Liu Y . Role of the B1 kinin receptor in the regulation of cardiac function and remodeling after myocardial infarction. Hypertension. 2005; 45(4):747-53. PMC: 4593484. DOI: 10.1161/01.HYP.0000153322.04859.81. View

19.

Griol-Charhbili V, Messadi-Laribi E, Bascands J, Heudes D, Meneton P, Giudicelli J . Role of tissue kallikrein in the cardioprotective effects of ischemic and pharmacological preconditioning in myocardial ischemia. FASEB J. 2005; 19(9):1172-4. DOI: 10.1096/fj.04-3508fje. View

20.

Koike M, de Carvalho Frimm C, Higuchi M . Bradykinin B2 receptor antagonism attenuates inflammation, mast cell infiltration and fibrosis in remote myocardium after infarction in rats. Clin Exp Pharmacol Physiol. 2006; 32(12):1131-6. DOI: 10.1111/j.1440-1681.2005.04309.x. View