Aeroallergen Sensitization in Healthy Children: Racial and Socioeconomic Correlates

Overview

Journal J Pediatr

Specialty Pediatrics

Date 2007 Jul 24

PMID 17643776

Citations 19

Authors

Michelle D Stevenson

Stacey Sellins

Emilie Grube

Kathy Schroer

Jayanta Gupta

Ning Wang

Gurjit K Khurana Hershey

Affiliations

Soon will be listed here.

Abstract

Objective: Allergic sensitization is very prevalent and often precedes the development of allergic disease. This study examined the association of race with allergic sensitization among healthy children with no family history of atopy.

Study Design: Two hundred seventy-five children, predominantly from lower socioeconomic strata, from Cincinnati, Ohio, ages 2 to 18 years without a family or personal history of allergic diseases, underwent skin prick testing to 11 allergen panels. The Pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) was used to examine the impact of sensitization on quality of life.

Results: Thirty-nine percent of healthy children were sensitized to 1 or more allergen panels. Multivariate logistic regression showed increased risk among African-American children for any sensitization (OR, 2.17; [95% CI: 1.23, 3.84]) and sensitization to any outdoor allergen (OR, 2.96 [95% CI: 1.52, 5.74]). Eighty-six percent of children had PADQLQ scores of 1 or less (0 to 6 scale).

Conclusions: Allergic sensitization is prevalent even among children who do not have a personal or family history of asthma, allergic rhinitis, or atopic dermatitis and who have no evidence of current, even subtle effects from this sensitization on allergic disease-related quality of life. African-American children are at greater risk for presence of sensitization, especially to outdoor allergens.

Citing Articles

Difficult-to-treat asthma patients from ethnic minority groups in central England are at an enhanced risk of house dust mite sensitisation.

Mansur A, Marsh J, Bahron A, Thomas M, Walters G, Busby J Clin Transl Allergy. 2023; 13(10):e12303.

PMID: 37876034 PMC: 10560749. DOI: 10.1002/clt2.12303.

Racial and Ethnic Disparities in Allergen Immunotherapy Prescription for Allergic Rhinitis.

Modi S, Norris M, Nguyen V, Bower R, Craig T, Al-Shaikhly T J Allergy Clin Immunol Pract. 2023; 11(5):1528-1535.e2.

PMID: 36736954 PMC: 10164679. DOI: 10.1016/j.jaip.2023.01.034.

Field Evaluation of an Automated Pollen Sensor.

Jiang C, Wang W, Du L, Huang G, McConaghy C, Fineman S Int J Environ Res Public Health. 2022; 19(11).

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Serum Allergen-Specific IgE among Pediatric Patients with Primary Immunodeficiency.

Pieniawska-Smiech K, Lewandowicz-Uszynska A, Zemelka-Wiacek M, Jutel M Children (Basel). 2022; 9(4).

PMID: 35455510 PMC: 9029572. DOI: 10.3390/children9040466.

Burden of allergic disease among ethnic minority groups in high-income countries.

Jones C, Paudyal P, West R, Mansur A, Jay N, Makwana N Clin Exp Allergy. 2022; 52(5):604-615.

PMID: 35306712 PMC: 9324921. DOI: 10.1111/cea.14131.

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