Diamines Interfere with the Transport of L-ornithine in Ehrlich-cell Plasma-membrane Vesicles

Overview

Journal Biochem J

Specialty Biochemistry

Date 1991 Dec 15

PMID 1764045

Citations 3

Authors

M A Medina

J L Urdiales

J M Mates

I Nunez de Castro

F Sanchez-Jimenez

Affiliations

Soon will be listed here.

Abstract

1. L-Ornithine transport by plasma-membrane vesicles isolated from Ehrlich cells is Na(+)-independent and shows a saturable and a diffusional component. 2. Putrescine, histamine, 5-hydroxytryptamine and 2,3-diaminopropane at 55 microM concentration significantly inhibit 0.5 mM-L-ornithine transport at least for the first 10 min of incubation. 3. There is a trans-stimulatory effect of putrescine on L-ornithine transport.

Citing Articles

Pharmacological potential of biogenic amine-polyamine interactions beyond neurotransmission.

Sanchez-Jimenez F, Ruiz-Perez M, Urdiales J, Medina M Br J Pharmacol. 2013; 170(1):4-16.

PMID: 23347064 PMC: 3764843. DOI: 10.1111/bph.12109.

AMMO-Prot: amine system project 3D-model finder.

Navas-Delgado I, Montanez R, Pino-Angeles A, Moya-Garcia A, Urdiales J, Sanchez-Jimenez F BMC Bioinformatics. 2008; 9 Suppl 4:S5.

PMID: 18460178 PMC: 2367632. DOI: 10.1186/1471-2105-9-S4-S5.

Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines.

Medina M, Garcia de Veas R, Morata P, Lozano J, Sanchez-Jimenez F Breast Cancer Res Treat. 1995; 35(2):187-94.

PMID: 7647340 DOI: 10.1007/BF00668208.

References

White M, Gazzola G, CHRISTENSEN H . Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts. J Biol Chem. 1982; 257(8):4443-9. View

MUNCK B . Lysine transport across the small intestine. Stimulating and inhibitory effects of neutral amino acids. J Membr Biol. 1980; 53(1):45-53. DOI: 10.1007/BF01871171. View

Bradford M . A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72:248-54. DOI: 10.1016/0003-2697(76)90527-3. View

White M, CHRISTENSEN H . Cationic amino acid transport into cultured animal cells. II. Transport system barely perceptible in ordinary hepatocytes, but active in hepatoma cell lines. J Biol Chem. 1982; 257(8):4450-7. View

Medina M, Quesada A, Nunez de Castro I . L-glutamine transport in native vesicles isolated from Ehrlich ascites tumor cell membranes. J Bioenerg Biomembr. 1991; 23(4):689-97. DOI: 10.1007/BF00785818. View

Luque P, Marquez J, Nunez de Castro I, Medina M . Sodium-dependent L-serine transport in plasma membrane vesicles isolated from Ehrlich cells by two-phase compartmentation. J Membr Biol. 1991; 123(3):247-54. DOI: 10.1007/BF01870407. View

Mates J, Sanchez-Jimenez F, Nunez de Castro I . Regulation by 1,4-diamines of the ornithine decarboxylase activity induced by ornithine in perifused tumor cells. Biochem Pharmacol. 1991; 42(5):1045-52. DOI: 10.1016/0006-2952(91)90287-f. View

Argiles J, Lopez-Soriano F . Intestinal amino acid transport: an overview. Int J Biochem. 1990; 22(9):931-7. DOI: 10.1016/0020-711x(90)90198-c. View

Morgan D . Polyamines and cellular regulation: perspectives. Biochem Soc Trans. 1990; 18(6):1080-4. DOI: 10.1042/bst0181080. View

10.

Pegg A . Recent advances in the biochemistry of polyamines in eukaryotes. Biochem J. 1986; 234(2):249-62. PMC: 1146560. DOI: 10.1042/bj2340249. View

11.

White M . The transport of cationic amino acids across the plasma membrane of mammalian cells. Biochim Biophys Acta. 1985; 822(3-4):355-74. DOI: 10.1016/0304-4157(85)90015-2. View

12.

Schuber F . Influence of polyamines on membrane functions. Biochem J. 1989; 260(1):1-10. PMC: 1138618. DOI: 10.1042/bj2600001. View

13.

Marquez J, Mates J, Quesada A, Medina M, Nunez de Castro I, Sanchez-Jimenez F . Altered ornithine metabolism in tumor-bearing mice. Life Sci. 1989; 45(20):1877-84. DOI: 10.1016/0024-3205(89)90541-9. View

14.

Rotoli B, Bussolati O, DallAsta V, Gazzola G . The transport of L-arginine in Chinese hamster ovary cells. Biochem Biophys Res Commun. 1989; 164(3):1093-8. DOI: 10.1016/0006-291x(89)91781-6. View

15.

Mates J, Garcia-Caballero M, Nunez de Castro I . Histamine and serotonin inhibit induction of ornithine decarboxylase by ornithine in perifused Ehrlich ascites tumour cells. FEBS Lett. 1989; 250(2):257-61. DOI: 10.1016/0014-5793(89)80733-1. View

16.

Medina M, Nunez de Castro I . Glutaminolysis and glycolysis interactions in proliferant cells. Int J Biochem. 1990; 22(7):681-3. DOI: 10.1016/0020-711x(90)90001-j. View

17.

Heby O, Persson L . Molecular genetics of polyamine synthesis in eukaryotic cells. Trends Biochem Sci. 1990; 15(4):153-8. DOI: 10.1016/0968-0004(90)90216-x. View

18.

Seiler N, Dezeure F . Polyamine transport in mammalian cells. Int J Biochem. 1990; 22(3):211-8. DOI: 10.1016/0020-711x(90)90332-w. View

19.

McCormick J, Tsang D, Johnstone R . A simple and efficient method for reconstitution of amino acid and glucose transport systems from Ehrlich ascites cells. Arch Biochem Biophys. 1984; 231(2):355-65. DOI: 10.1016/0003-9861(84)90398-9. View

20.

Rinehart Jr C, Chen K . Characterization of the polyamine transport system in mouse neuroblastoma cells. Effects of sodium and system A amino acids. J Biol Chem. 1984; 259(8):4750-6. View