Thymosin Beta4 and Angiogenesis: Modes of Action and Therapeutic Potential

Overview

Journal Angiogenesis

Publisher Springer

Specialty Hematology

Date 2007 Jul 17

PMID 17632766

Citations 44

Authors

Nicola Smart

Alex Rossdeutsch

Paul R Riley

Affiliations

Soon will be listed here.

Abstract

Here we review the mechanisms by which Thymosin beta4 (Tbeta4) regulates angiogenesis, its role in processes, such as wound healing and tumour progression and we discuss in more detail the role of Tbeta4 in the cardiovascular system and significant recent findings implicating Tbeta4 as a potential therapeutic agent for ischaemic heart disease.

Citing Articles

Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling.

Mcleod J, Lim C, Stokes T, Sharif J, Zeynalli V, Wiens L NAR Mol Med. 2024; 1(4):ugae016.

PMID: 39669123 PMC: 11632610. DOI: 10.1093/narmme/ugae016.

Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling.

Mcleod J, Lim C, Stokes T, Sharif J, Zeynalli V, Wiens L bioRxiv. 2024; .

PMID: 39416175 PMC: 11482748. DOI: 10.1101/2024.08.11.606848.

Th22 is the effector cell of thymosin β15-induced hair regeneration in mice.

Tao N, Ying Y, Xu X, Sun Q, Shu Y, Hu S Inflamm Regen. 2024; 44(1):3.

PMID: 38191481 PMC: 10773137. DOI: 10.1186/s41232-023-00316-z.

Protection effect of thymosin β4 on ethanol injury in corneal stromal keratocyte.

Liu J, Guo C, Hao P, Wang P, Li L, Wang Y BMC Ophthalmol. 2022; 22(1):33.

PMID: 35062902 PMC: 8783420. DOI: 10.1186/s12886-022-02255-8.

Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis.

Lachowicz J, Pichiri G, Piludu M, Fais S, Orru G, Congiu T Int J Mol Sci. 2022; 23(1).

PMID: 35008976 PMC: 8745404. DOI: 10.3390/ijms23010551.