Neuronal Migration: Unraveling the Molecular Pathway with Humans, Mice, and a Fungus

Overview

Journal Mamm Genome

Specialty Genetics

Date 2007 Jul 17

PMID 17629745

Citations 7

Authors

David A Keays

Affiliations

Soon will be listed here.

Abstract

This review highlights the utility of comparative genetics in understanding the molecular mechanisms that underlie neuronal migration. It is apparent from studies in humans, mice, and a fungus that nuclear migration is a key component of neuronal migration and that both are dependent on a dynamic microtubule network. In vertebrates regulation of this network involves a complex pathway that is dependent on extracellular guidance cues, membrane-bound receptors, intracellular signaling molecules, proteins associated with microtubules, and the components of microtubules themselves.

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