Distinct Epidermal Stem Cell Compartments Are Maintained by Independent Niche Microenvironments

Overview

Journal Stem Cell Rev

Specialty Cell Biology

Date 2007 Jul 13

PMID 17625258

Citations 15

Authors

Kristin M Braun

David M Prowse

Affiliations

Soon will be listed here.

Abstract

The mammalian epidermis is a stratified, multilayered epithelium, consisting of the interfollicular epidermis and associated appendages, which extend into the dermis and include hair follicles, sebaceous glands, and sweat glands. Stem cells are essential for the maintenance of this tissue and are also potential sources of multipotent adult precursor cells. Stem cell populations occupying specific locations or niches have been identified in the interfollicular epidermis, the hair follicle and the sebaceous gland. Recent research has focused on how the stem cell niches provide specific sites where stem cells can reside indefinitely and undergo self-renewal or differentiation into specific cell lineages, as required for epidermal replenishment or hair follicle growth.

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