Skeletal Muscle Morphology in Patients with Restless Legs Syndrome
Overview
Affiliations
Aim: The aim of the study was to assess the cellular and structural properties of skeletal muscle in restless legs syndrome (RLS).
Method: Twenty patients and 16 controls were included. Aerobic performance was assessed using a submaximal test. On muscle biopsies taken from the tibialis anterior, fiber distribution and fiber area were analyzed together with parameters surveying the microvascularization, especially the tortuosity, which is expressed as a percent of muscle fiber perimeter in contact with the wall of the microvessel, length of capillary/perimeter of fiber (LC/PF) index.
Results: The RLS group had significantly lower predicted maximal oxygen uptake (p = 0.01) and significantly higher LC/PF index (p = 0.01) compared to the controls.
Conclusion: The higher capillary tortuosity in RLS patients indicates the occurrence of significant remodeling in capillary geometry in RLS.
Sarcopenia Seems to Be Common in Older Patients With Restless Legs Syndrome.
Gokdeniz Yildirim A, Kaya D, Dost F, Ontan M, Isik A J Cachexia Sarcopenia Muscle. 2024; 16(1):e13637.
PMID: 39568327 PMC: 11670161. DOI: 10.1002/jcsm.13637.
Unfolding the role of exercise in the management of sleep disorders.
Giannaki C, Sakkas G, Hadjigeorgiou G, Manconi M, Bargiotas P Eur J Appl Physiol. 2024; 124(9):2547-2560.
PMID: 39031176 PMC: 11365864. DOI: 10.1007/s00421-024-05556-6.
Myoclonus and other jerky movement disorders.
van der Veen S, Caviness J, Dreissen Y, Ganos C, Ibrahim A, Koelman J Clin Neurophysiol Pract. 2022; 7:285-316.
PMID: 36324989 PMC: 9619152. DOI: 10.1016/j.cnp.2022.09.003.
Manconi M, Garcia-Borreguero D, Schormair B, Videnovic A, Berger K, Ferri R Nat Rev Dis Primers. 2021; 7(1):80.
PMID: 34732752 DOI: 10.1038/s41572-021-00311-z.
Jimenez-Jimenez F, Agundez B, Gomez-Tabales J, Alonso-Navarro H, Turpin-Fenoll L, Millan-Pascual J Front Pharmacol. 2021; 12:618989.
PMID: 33732155 PMC: 7959806. DOI: 10.3389/fphar.2021.618989.