Role of Placentally Produced Inflammatory and Regulatory Cytokines in Pregnancy and the Etiology of Preeclampsia

Overview

Journal Semin Immunopathol

Publisher Springer

Specialties Allergy & Immunology
Pathology

Date 2007 Jul 12

PMID 17621700

Citations 67

Authors

Corinne Rusterholz

Sinuhe Hahn

Wolfgang Holzgreve

Affiliations

Soon will be listed here.

Abstract

Human pregnancy is a metabolic and immune challenge for the mother who has to accommodate in her womb a semi-allogeneic fetus whose energy needs increase tremendously with gestation. Recent compelling research has suggested that proper inflammatory changes and oxidative balance are a requisite for successful pregnancy. The placenta is an integral component of this inflammatory response as it actively produces a variety of cytokines and immunomodulatory hormones. In preeclampsia, a life-threatening disorder of pregnancy that is characterized by widespread damage and dysfunction of the maternal endothelium, placental oxidative stress and aberrant cytokine expression induces an exaggerated maternal systemic inflammatory response to pregnancy.

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