Effects of Acoustic Parameters on Bubble Cloud Dynamics in Ultrasound Tissue Erosion (histotripsy)

Overview

Journal J Acoust Soc Am

Publisher American Institute of Physics

Specialty Otorhinolaryngology

Date 2007 Jul 7

PMID 17614482

Citations 41

Authors

Zhen Xu

Timothy L Hall

J Brian Fowlkes

Charles A Cain

Affiliations

Soon will be listed here.

Abstract

High intensity pulsed ultrasound can produce significant mechanical tissue fractionation with sharp boundaries ("histotripsy"). At a tissue-fluid interface, histotripsy produces clearly demarcated tissue erosion and the erosion efficiency depends on pulse parameters. Acoustic cavitation is believed to be the primary mechanism for the histotripsy process. To investigate the physical basis of the dependence of tissue erosion on pulse parameters, an optical method was used to monitor the effects of pulse parameters on the cavitating bubble cloud generated by histotripsy pulses at a tissue-water interface. The pulse parameters studied include pulse duration, peak rarefactional pressure, and pulse repetition frequency (PRF). Results show that the duration of growth and collapse (collapse cycle) of the bubble cloud increased with increasing pulse duration, peak rarefactional pressure, and PRF when the next pulse arrived after the collapse of the previous bubble cloud. When the PRF was too high such that the next pulse arrived before the collapse of the previous bubble cloud, only a portion of histotripsy pulses could effectively create and collapse the bubble cloud. The collapse cycle of the bubble cloud also increased with increasing gas concentration. These results may explain previous in vitro results on effects of pulse parameters on tissue erosion.

Citing Articles

Histotripsy-Induced Bactericidal Activity Correlates to Size of Cavitation Cloud In Vitro.

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A comparative study of histotripsy parameters for the treatment of fibrotic ex-vivo human benign prostatic hyperplasia tissue.

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A Comparative Study of Histotripsy Parameters for the Treatment of Fibrotic ex-vivo Human Benign Prostatic Hyperplasia Tissue.

Kumar Y, Singh Z, Wang Y, Kanabolo D, Chen L, Bruce M Res Sq. 2024; .

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Enhancement of Boiling Histotripsy by Steering the Focus Axially During the Pulse Delivery.

Thomas G, Khokhlova T, Sapozhnikov O, Khokhlova V IEEE Trans Ultrason Ferroelectr Freq Control. 2023; 70(8):865-875.

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Soft Tissue Aberration Correction for Histotripsy Using Acoustic Emissions From Cavitation Cloud Nucleation and Collapse.

Yeats E, Lu N, Sukovich J, Xu Z, Hall T Ultrasound Med Biol. 2023; 49(5):1182-1193.

PMID: 36759271 PMC: 10082475. DOI: 10.1016/j.ultrasmedbio.2023.01.004.

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