Effects of Parenteral Diclofenac Sodium on Upper Gastrointestinal Motility After Food in Man

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1991 Jan 1

PMID 1761083

Citations 4

Authors

G Bassotti

G Bucaneve

C Betti

L Patoia

E Baratta

V Maresca

M A Pelli

A Morelli

A Del Favero

Affiliations

Soon will be listed here.

Abstract

In experimental animal models nonsteroidal anti-inflammatory drugs may influence gastrointestinal motility, but as evidence is lacking in man. The effect of diclofenac sodium 75 mg i.m. on the motor response of the upper gastrointestinal tract to food has been studied by manometry in 9 healthy volunteers. Diclofenac had no effect on the motor activity of the stomach, duodenum, or jejunum after a 605 kcal meal.

Citing Articles

Double-blind, placebo-controlled study on effects of diclofenac sodium and indomethacin on postprandial gastric motility in man.

Bassotti G, Bucaneve G, FURNO P, Morelli A, Del Favero A Dig Dis Sci. 1998; 43(6):1172-6.

PMID: 9635603 DOI: 10.1023/a:1018883102636.

Effects of octreotide on manometric variables in patients with neuropathic abnormalities of the small bowel.

Bassotti G, Germani U, Calcara C, Spinozzi F, Roselli P, Morelli A Dig Dis Sci. 1997; 42(8):1634-9.

PMID: 9286228 DOI: 10.1023/a:1018845011625.

Abnormal gastrointestinal motility in patients with celiac sprue.

Bassotti G, Castellucci G, Betti C, Fusaro C, Cavalletti M, Bertotto A Dig Dis Sci. 1994; 39(9):1947-54.

PMID: 8082502 DOI: 10.1007/BF02088130.

Pharmacokinetic considerations in gastrointestinal motor disorders.

Hebbard G, Sun W, Bochner F, Horowitz M Clin Pharmacokinet. 1995; 28(1):41-66.

PMID: 7712661 DOI: 10.2165/00003088-199528010-00005.

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