No Association Between TGFBR1*6A and Lung Cancer

Overview

Journal J Thorac Oncol

Publisher Elsevier

Specialties Oncology
Pulmonary Medicine

Date 2007 Jul 4

PMID 17607123

Citations 11

Authors

Weiming You

Zeyi Liu

Jun Zhao

Mingfeng Zheng

Shi-Ying Zheng

Xia Liu

Hong-Tao Zhang

Affiliations

Soon will be listed here.

Abstract

Introduction: TGFBR1*6A, a functionally polymorphic allele in the transforming growth factor [beta] receptor 1 gene (TGFBR1), has been hypothesized to increase risk of various cancers. However, little has been documented about connection of this variant with lung cancer.

Methods: In an attempt to explore whether the TGFBR1*6A is associated with lung cancer, we performed genotyping followed by sequencing in 252 patients with lung cancer and 250 healthy controls.

Results: The frequency for the heterozygote 9A/6A is 13.9% in cases compared with 12.4% in controls, and the odds ratio is 1.14 (95% confidence interval: 0.68-1.91), which is not statistically significant (p = 0.62), suggesting that TGFBR1*6A could not be a cancer susceptibility factor for Chinese patients with lung cancer.

Conclusions: We have no evidence to support the hypothesis that TGFBR1*6A is associated with lung cancer.

Citing Articles

Association between TGFBR1 polymorphisms and cancer risk: a meta-analysis of 35 case-control studies.

Wang Y, Qi X, Wang F, Jiang J, Guo Q PLoS One. 2012; 7(8):e42899.

PMID: 22905183 PMC: 3414489. DOI: 10.1371/journal.pone.0042899.

Debate about TGFBR1 and the susceptibility to colorectal cancer.

Valle L World J Gastrointest Oncol. 2012; 4(1):1-8.

PMID: 22347533 PMC: 3277874. DOI: 10.4251/wjgo.v4.i1.1.

Transforming growth factor β signaling pathway associated gene polymorphisms may explain lower breast cancer risk in western Indian women.

Joshi N, Kale M, Hake S, Kannan S PLoS One. 2011; 6(8):e21866.

PMID: 21829601 PMC: 3150347. DOI: 10.1371/journal.pone.0021866.

Association of polymorphisms in transforming growth factor-β receptors with susceptibility to gastric cardia adenocarcinoma.

Guo W, Dong Z, Guo Y, Chen Z, Yang Z, Kuang G Mol Biol Rep. 2011; 39(4):4301-9.

PMID: 21785915 DOI: 10.1007/s11033-011-1217-0.

Genetic variations in the transforming growth factor-beta pathway as predictors of survival in advanced non-small cell lung cancer.

Lin M, Stewart D, Spitz M, Hildebrandt M, Lu C, Lin J Carcinogenesis. 2011; 32(7):1050-6.

PMID: 21515830 PMC: 3128559. DOI: 10.1093/carcin/bgr067.