Ozone and Pulmonary Innate Immunity

Overview

Journal Proc Am Thorac Soc

Specialty Pulmonary Medicine

Date 2007 Jul 4

PMID 17607006

Citations 68

Authors

John W Hollingsworth

Steven R Kleeberger

W Michael Foster

Affiliations

Soon will be listed here.

Abstract

Ambient ozone (O(3)) is a commonly encountered environmental air pollutant with considerable impact on public health. Many other inhaled environmental toxicants can substantially affect pulmonary immune responses. Therefore, it is of considerable interest to better understand the complex interaction between environmental airway irritants and immunologically based human disease. The innate immune system represents the first line of defense against microbial pathogens. Intact innate immunity requires maintenance of an intact barrier to interface with the external environment, effective phagocytosis of microbial pathogens, and precise detection of pathogen-associated molecular patterns. We use ambient O(3) as a model to highlight the importance of understanding the role of exposure to ubiquitous air toxins and regulation of basic immune function. Inhalation of O(3) is associated with impaired antibacterial host defense, in part related to disruption of epithelial barrier and effective phagocytosis of pathogens. The functional response to ambient O(3) seems to be dependent on many components of the innate immune signaling. In this article, we review the complex interaction between inhalation of O(3) and pulmonary innate immunity.

Citing Articles

Tissue-Resident Alveolar Macrophages Reduce Ozone-induced Inflammation via MerTK-mediated Efferocytosis.

Guttenberg M, Vose A, Birukova A, Lewars K, Cumming R, Albright M Am J Respir Cell Mol Biol. 2024; 70(6):493-506.

PMID: 38386777 PMC: 11160417. DOI: 10.1165/rcmb.2023-0390OC.

Involvement and repair of epithelial barrier dysfunction in allergic diseases.

Lu H, Zhou Y, Yang L, Zhou Q, Wang X, Qiu S Front Immunol. 2024; 15:1348272.

PMID: 38361946 PMC: 10867171. DOI: 10.3389/fimmu.2024.1348272.

Tissue-resident alveolar macrophages reduce O-induced inflammation via MerTK mediated efferocytosis.

Guttenberg M, Vose A, Birukova A, Lewars K, Cumming R, Albright M bioRxiv. 2023; .

PMID: 37986982 PMC: 10659406. DOI: 10.1101/2023.11.06.565865.

Chemical exposure and alveolar macrophages responses: 'the role of pulmonary defense mechanism in inhalation injuries'.

Tapak M, Sadeghi S, Ghazanfari T, Mosaffa N BMJ Open Respir Res. 2023; 10(1).

PMID: 37479504 PMC: 10364189. DOI: 10.1136/bmjresp-2022-001589.

Novel method to assess resident alveolar macrophage efferocytosis of apoptotic neutrophils by flow cytometry.

Radbel J, Meshanni J, Gardner C, Le-Hoang O, Cervelli J, Laskin J Toxicol Appl Pharmacol. 2022; 460:116359.

PMID: 36565939 PMC: 9870943. DOI: 10.1016/j.taap.2022.116359.

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