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The X Factor: Skewing X Inactivation Towards Cancer

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 2007 Jul 3
PMID 17604714
Citations 19
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Abstract

Increased expression of the epidermal growth factor receptor HER-2/ErbB2 is frequently observed in breast cancer and is targeted by the anticancer drug Herceptin. Now, Zuo et al. (2007) reveal that an X-linked gene encoding the transcription factor FOXP3 is a breast cancer tumor suppressor that represses expression of HER2/ErbB2.

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