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Immortal Strands? Give Me a Break

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 2007 Jul 3
PMID 17604711
Citations 96
Authors
Affiliations
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Abstract

The "immortal strand" hypothesis proposes that asymmetrically dividing stem cells selectively retain chromosomes containing "old" DNA to prevent accumulation of mutations. As I describe in this Essay, such a possibility seems unlikely. An alternative explanation is that asymmetric cell divisions and cell fate are codirected by epigenetic differences between sister chromatids.

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