New Chemically Induced Skin Tumour Susceptibility Loci Identified in a Mouse Backcross Between FVB and Dominant Resistant PWK

Overview

Journal BMC Genet

Publisher Biomed Central

Specialties Biotechnology
Molecular Biology

Date 2007 Jun 30

PMID 17598916

Citations 14

Authors

Kyoko Fujiwara

Jun Igarashi

Natsumi Irahara

Makoto Kimura

Hiroki Nagase

Affiliations

Soon will be listed here.

Abstract

Background: A variety of skin cancer susceptibility among mouse strains has allowed identification of genes responsible for skin cancer development. Fifteen Skts loci for skin tumour susceptibility have been mapped so far by using the two-stage skin carcinogenesis model [induced by 7.12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)]. A few responsible genes have been identified using wild-derived dominant resistant Mus spretus mice, and one has been confirmed as a low penetrance cancer susceptibility gene in a variety of human cancers.

Results: In the present study, we found that wild-derived PWK mice developed no tumour by treatment with the two-stage skin carcinogenesis protocol. This phenotype is dominant resistant when crossed with the highly susceptible strain FVB. By analyzing the F1 backcross generation between PWK and FVB, we found empirical evidence of significant linkage at the new loci Skts-fp1 on chromosome 4 and suggestive linkage on chromosomes 1, 3, 11, 12 and 14 for skin tumour susceptibility. Skts-fp1 includes the Skts7 interval, which was previously mapped by a Mus spretus and NIH backcross. We also observed suggestive linkage on chromosomes 1 and 2 in the female population only, while suggestive linkage on chromosomes 14 and 15 only was observed in the male population. A significant genetic interaction was seen between markers of D11Mit339 and D16Mit14.

Conclusion: Analysis of this new cross may facilitate the identification of genes responsible for mouse skin cancer susceptibility and may reveal their biological interactions.

Citing Articles

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The Japanese Wild-Derived Inbred Mouse Strain, MSM/Ms in Cancer Research.

Okumura K, Saito M, Isogai E, Wakabayashi Y Cancers (Basel). 2021; 13(5).

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A wild-derived inbred mouse strain, MSM/Ms, provides insights into novel skin tumor susceptibility genes.

Okumura K, Saito M, Wakabayashi Y Exp Anim. 2021; 70(3):272-283.

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Mapping of new skin tumor susceptibility loci by a phenotype-driven congenic approach.

Fujiwara K, Inagaki Y, Soma M, Ozaki T, Nagase H Oncol Lett. 2018; 16(5):6670-6676.

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The parathyroid hormone regulates skin tumour susceptibility in mice.

Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I Sci Rep. 2017; 7(1):11208.

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