DCAFs, the Missing Link of the CUL4-DDB1 Ubiquitin Ligase

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2007 Jun 26

PMID 17588513

Citations 257

Authors

Jennifer Lee

Pengbo Zhou

Affiliations

Soon will be listed here.

Abstract

The CUL4-DDB1 ubiquitin ligase regulates cell proliferation, survival, DNA repair, and genomic integrity through targeted ubiquitination of key regulators, yet the substrate receptors that dictate the specificity of this ubiquitination machinery have been largely unknown. Recent work identified a family of DDB1 and CUL4-associated factors (DCAFs) as substrate receptors, implicating a broad spectrum of cellular processes regulated by CUL4-DDB1.

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