Spatio-temporal Specification of Olfactory Bulb Interneurons

Overview

Journal J Mol Histol

Specialty Biochemistry

Date 2007 Jun 26

PMID 17588153

Citations 14

Authors

Serena Bovetti

Paolo Peretto

Aldo Fasolo

Silvia De Marchis

Affiliations

Soon will be listed here.

Abstract

Olfactory bulb (OB) interneurons are continuously generated throughout development and in adulthood, and are derived from different progenitor zones. Once integrated in the OB circuits, interneurons play essential roles in olfactory information processing by modulating the activity of major output neurons. These functions are performed by multiple classes of neurons that differ in their spatial distribution, morphology, neurochemical and synaptic properties. This diversity, and the continuous neurogenesis make the understanding of the specification mechanisms in the OB a challenging task. New studies suggest that both intrinsic and extrinsic cues are involved in fate determination of OB interneurons. In both development and adulthood the expression of specific transcription factors not only defines different progenitor regions but also precise interneuronal phenotypes. Here we discuss recent findings on the molecular mechanisms regulating production and diversity of OB interneurons with respect to the spatial and temporal parameters.

Citing Articles

Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs.

Butruille L, Sebillot A, Avila K, Vancamp P, Demeneix B, Pifferi F Stem Cell Reports. 2023; 18(2):534-554.

PMID: 36669492 PMC: 9969077. DOI: 10.1016/j.stemcr.2022.12.015.

Distinct Developmental Features of Olfactory Bulb Interneurons.

Kim J, Choe J Mol Cells. 2020; 43(3):215-221.

PMID: 32208366 PMC: 7103883. DOI: 10.14348/molcells.2020.0033.

Adult Born Olfactory Bulb Dopaminergic Interneurons: Molecular Determinants and Experience-Dependent Plasticity.

Bonzano S, Bovetti S, Gendusa C, Peretto P, De Marchis S Front Neurosci. 2016; 10:189.

PMID: 27199651 PMC: 4858532. DOI: 10.3389/fnins.2016.00189.

Brain homeostasis: VEGF receptor 1 and 2-two unequal brothers in mind.

Wittko-Schneider I, Schneider F, Plate K Cell Mol Life Sci. 2013; 70(10):1705-25.

PMID: 23475067 PMC: 3632714. DOI: 10.1007/s00018-013-1279-3.

Spatiotemporal changes to the subventricular zone stem cell pool through aging.

Shook B, Manz D, Peters J, Kang S, Conover J J Neurosci. 2012; 32(20):6947-56.

PMID: 22593063 PMC: 3359841. DOI: 10.1523/JNEUROSCI.5987-11.2012.

References

Corbin J, Gaiano N, Machold R, Langston A, Fishell G . The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. Development. 2000; 127(23):5007-20. DOI: 10.1242/dev.127.23.5007. View

Luskin M . Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron. 1993; 11(1):173-89. DOI: 10.1016/0896-6273(93)90281-u. View

Baker H, Morel K, Stone D, Maruniak J . Adult naris closure profoundly reduces tyrosine hydroxylase expression in mouse olfactory bulb. Brain Res. 1993; 614(1-2):109-16. DOI: 10.1016/0006-8993(93)91023-l. View

Lemasson M, Saghatelyan A, Olivo-Marin J, Lledo P . Neonatal and adult neurogenesis provide two distinct populations of newborn neurons to the mouse olfactory bulb. J Neurosci. 2005; 25(29):6816-25. PMC: 6725349. DOI: 10.1523/JNEUROSCI.1114-05.2005. View

Stenman J, Toresson H, Campbell K . Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis. J Neurosci. 2003; 23(1):167-74. PMC: 6742158. View

Corotto F, Henegar J, Maruniak J . Odor deprivation leads to reduced neurogenesis and reduced neuronal survival in the olfactory bulb of the adult mouse. Neuroscience. 1994; 61(4):739-44. DOI: 10.1016/0306-4522(94)90397-2. View

Baker H, Liu N, Chun H, Saino S, Berlin R, Volpe B . Phenotypic differentiation during migration of dopaminergic progenitor cells to the olfactory bulb. J Neurosci. 2001; 21(21):8505-13. PMC: 6762814. View

Kosaka K, Kosaka T . synaptic organization of the glomerulus in the main olfactory bulb: compartments of the glomerulus and heterogeneity of the periglomerular cells. Anat Sci Int. 2005; 80(2):80-90. DOI: 10.1111/j.1447-073x.2005.00092.x. View

Parrish-Aungst S, Shipley M, Erdelyi F, Szabo G, Puche A . Quantitative analysis of neuronal diversity in the mouse olfactory bulb. J Comp Neurol. 2007; 501(6):825-36. DOI: 10.1002/cne.21205. View

10.

De Marchis S, Temoney S, Erdelyi F, Bovetti S, Bovolin P, Szabo G . GABAergic phenotypic differentiation of a subpopulation of subventricular derived migrating progenitors. Eur J Neurosci. 2004; 20(5):1307-17. DOI: 10.1111/j.1460-9568.2004.03584.x. View

11.

Sussel L, Marin O, Kimura S, Rubenstein J . Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development. 1999; 126(15):3359-70. DOI: 10.1242/dev.126.15.3359. View

12.

Toresson H, Campbell K . A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice. Development. 2001; 128(23):4769-80. DOI: 10.1242/dev.128.23.4769. View

13.

Levi G, Puche A, Mantero S, Barbieri O, Trombino S, Paleari L . The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse. Mol Cell Neurosci. 2003; 22(4):530-43. DOI: 10.1016/s1044-7431(02)00041-6. View

14.

Hinds J . Autoradiographic study of histogenesis in the mouse olfactory bulb. I. Time of origin of neurons and neuroglia. J Comp Neurol. 1968; 134(3):287-304. DOI: 10.1002/cne.901340304. View

15.

Stuhmer T, Puelles L, Ekker M, Rubenstein J . Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons. Cereb Cortex. 2001; 12(1):75-85. DOI: 10.1093/cercor/12.1.75. View

16.

Petreanu L, Alvarez-Buylla A . Maturation and death of adult-born olfactory bulb granule neurons: role of olfaction. J Neurosci. 2002; 22(14):6106-13. PMC: 6757952. DOI: 20026588. View

17.

Liu J, Ghattas I, Liu S, Chen S, Rubenstein J . Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation. Dev Dyn. 1998; 210(4):498-512. DOI: 10.1002/(SICI)1097-0177(199712)210:4<498::AID-AJA12>3.0.CO;2-3. View

18.

Saghatelyan A, de Chevigny A, Schachner M, Lledo P . Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain. Nat Neurosci. 2004; 7(4):347-56. DOI: 10.1038/nn1211. View

19.

Bulfone A, Wang F, Hevner R, Anderson S, Cutforth T, Chen S . An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron. 1999; 21(6):1273-82. DOI: 10.1016/s0896-6273(00)80647-9. View

20.

Wichterle H, Garcia-Verdugo J, Herrera D, Alvarez-Buylla A . Young neurons from medial ganglionic eminence disperse in adult and embryonic brain. Nat Neurosci. 1999; 2(5):461-6. DOI: 10.1038/8131. View