Polyketides, Proteins and Genes in Fungi: Programmed Nano-machines Begin to Reveal Their Secrets

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2007 Jun 22

PMID 17581644

Citations 169

Authors

Russell J Cox

Affiliations

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Abstract

Fungi produce a wide variety of biologically active compounds. Among these, the polyketides form a large and structurally diverse group. These compounds are synthesised by highly programmed and very large iterative multifunctional proteins, the polyketide synthases, with nm dimensions. This review outlines the current state of knowledge regarding the links between gene sequence, protein architecture and biosynthetic programming for fungal polyketide synthases.

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