Efavirenz to Nevirapine Switch in HIV-1-infected Patients with Dyslipidemia: a Randomized, Controlled Study

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2007 Jun 21

PMID 17578790

Citations 10

Authors

Jean-Jacques Parienti

Veronique Massari

David Rey

Patrice Poubeau

Renaud Verdon

Affiliations

Soon will be listed here.

Abstract

Many antiretroviral therapies, including efavirenz, are associated with increased serum concentrations of low-density lipoprotein cholesterol. In a small 52-week randomized study, we found that switching from efavirenz to nevirapine was associated with significantly decreased low-density lipoprotein cholesterol levels, compared with continuation of efavirenz therapy (P<.04). A switch to nevirapine was associated with no severe adverse events.

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