IL-2 Signals Through Sgk1 and Inhibits Proliferation and Apoptosis in Kidney Cancer Cells

Overview

Journal J Mol Med (Berl)

Specialty General Medicine

Date 2007 Jun 16

PMID 17571248

Citations 31

Authors

Rosario Amato

Miranda Menniti

Valter Agosti

Rosalia Boito

Nicola Costa

Heather M Bond

Vito Barbieri

Pierosandro Tagliaferri

Salvatore Venuta

Nicola Perrotti

Affiliations

Soon will be listed here.

Abstract

The interleukin-2 is a cytokine that is essential for lymphocytic survival and function. Ectopic expression of the IL-2 receptor in epithelial tissues has been reported previously, although the functional significance of this expression is still being investigated. We provided novel structural and functional information on the expression of the IL-2 receptor in kidney cancer cells and in other normal and neoplastic human epithelial tissues. In A-498 kidney cancer cells, we showed that IL-2 binding to its own receptor triggers a signal transduction pathway leading to the inhibition of proliferation and apoptosis. We found that the inhibition of proliferation is associated with Erk1/2 dephosphorylation, whereas the survival signals appear to be mediated by Sgk1 activation. This investigation focuses on the IL-2 induced regulation of Sgk1 and describes a role of the IL-2 receptor and Sgk1 in the regulation of epithelial tumor cell death and survival.

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