Infant Programming of Bone Size and Bone Mass in 10-year-old Black and White South African Children

In developed countries, the earliest of factors shown to identify those at a high risk of having low bone mass and so be prone to osteoporosis in later life is that of quality of early life reflected by low birthweight (BW) and size in infancy. It is unclear whether such relationships exist in developing countries and in black populations. Associations were studied between BW, weight (WT1) and length (LT1) at 1 year and bone size and bone mass in 476 children (boys: 182 black, 72 white; girls: 158 black, 64 white) aged 10 years, who formed part of a longitudinal cohort of children born in Johannesburg, South Africa, during 1990. Bone area (BA) and bone mineral content (BMC) measurements were made of the whole body, femoral neck and lumbar spine (L1-L4) by dual-energy X-ray absorptiometry (DXA). After adjusting BA and BMC for race, gender, age, socio-economic status, bone age, height and weight at 10 years, on which BA and BMC in children are so dependent, WT1, LT1 and BW were significant predictors of whole body BA (WT1, P < 0.0001; LT1, P < 0.01; BW, P < 0.05) and BMC (WT1, P < 0.01; LT1, P < 0.05; BW, P < 0.05) and of BMC of the femoral neck (WT1, P < 0.01; LT1, P < 0.05). When BMC was in addition corrected for BA, then BW, WT1 and LT1 were predictive of femoral neck BMC (BW, P < 0.05; WT1, P < 0.05; LT1, P < 0.01) but not whole body BMC. Thus, BMC at 10 years appears to be independently associated with weight and length at 1 year, which is not completely mediated by the tracking of skeletal growth. Low BW and small size at 1 year resulted in smaller bones and/or bones of lower BMC at the femoral neck. The findings support the hypothesis that growth and development, both intrauterine and in the first year, which are measures of genetic, intrauterine and postnatal environmental factors, may have long-term consequences when compromised, and may be associated with the risk of osteoporosis in later life.