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The Coming of Age for Piwi Proteins

Overview
Journal Mol Cell
Publisher Cell Press
Specialty Cell Biology
Date 2007 Jun 15
PMID 17560367
Citations 132
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Abstract

Piwi proteins, a subfamily of Argonaute (Ago) proteins, have recently been shown to bind endogenous small RNAs. However, differences between Ago proteins (which bind microRNAs and small interfering RNAs) and Piwi proteins and Piwi-interacting RNAs (piRNAs) suggest novel functions for Piwi proteins. Here, we highlight the recent progress in understanding Piwi function and the implications for germline and stem cell development.

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