Mouse Duplicate Genes Are As Essential As Singletons

Overview

Journal Trends Genet

Specialty Genetics

Date 2007 Jun 15

PMID 17559966

Citations 69

Authors

Ben-Yang Liao

Jianzhi Zhang

Affiliations

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Abstract

Duplicate genes in mouse are widely thought to have functional redundancy, and to be less essential than singleton genes. We analyzed nearly 3900 individually knocked out mouse genes and discovered that the proportion of essential genes is approximately 55% in both singletons and duplicates. This suggests that mammalian duplicates rarely compensate for each other, and that the absence of phenotypes in mice deficient for a duplicate gene should not be automatically attributed to paralogous compensation.

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