Computerized Acoustic Assessment of Treatment Efficacy of Nebulized Epinephrine and Albuterol in RSV Bronchiolitis

Overview

Journal BMC Pediatr

Publisher Biomed Central

Specialty Pediatrics

Date 2007 Jun 5

PMID 17543129

Citations 9

Authors

Raphael Beck

Nael Elias

Shay Shoval

Naveh Tov

Gil Talmon

Simon Godfrey

Lea Bentur

Affiliations

Soon will be listed here.

Abstract

Aim: We evaluated the use of computerized quantification of wheezing and crackles compared to a clinical score in assessing the effect of inhaled albuterol or inhaled epinephrine in infants with RSV bronchiolitis.

Methods: Computerized lung sounds analysis with quantification of wheezing and crackles and a clinical score were used during a double blind, randomized, controlled nebulized treatment pilot study. Infants were randomized to receive a single dose of 1 mgr nebulized l-epinephrine or 2.5 mgr nebulized albuterol. Computerized quantification of wheezing and crackles (PulmoTrack) and a clinical score were performed prior to, 10 minutes post and 30 minutes post treatment. Results were analyzed with Student's t-test for independent samples, Mann-Whitney U test and Wilcoxon test.

Results: 15 children received albuterol, 12 received epinephrine. The groups were identical at baseline. Satisfactory lung sounds recording and analysis was achieved in all subjects. There was no significant change in objective quantification of wheezes and crackles or in the total clinical scores either within the groups or between the groups. There was also no difference in oxygen saturation and respiratory distress.

Conclusion: Computerized lung sound analysis is feasible in young infants with RSV bronchiolitis and provides a non-invasive, quantitative measure of wheezing and crackles in these infants.

Citing Articles

Wheeze Recognition Algorithm for Remote Medical Care Device in Children: Validation Study.

Habukawa C, Ohgami N, Arai T, Makata H, Tomikawa M, Fujino T JMIR Pediatr Parent. 2021; 4(2):e28865.

PMID: 33875413 PMC: 8277407. DOI: 10.2196/28865.

A wheeze recognition algorithm for practical implementation in children.

Habukawa C, Ohgami N, Matsumoto N, Hashino K, Asai K, Sato T PLoS One. 2020; 15(10):e0240048.

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Network Meta-Analysis Comparing the Efficacy of Therapeutic Treatments for Bronchiolitis in Children.

Guo C, Sun X, Wang X, Guo Q, Chen D JPEN J Parenter Enteral Nutr. 2018; 42(1):186-195.

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Systematic review of instruments aimed at evaluating the severity of bronchiolitis.

Rodriguez-Martinez C, Sossa-Briceno M, Nino G Paediatr Respir Rev. 2017; 25:43-57.

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Nebulized Magnesium Sulfate in Acute Bronchiolitis: A Randomized Controlled Trial.

Modaresi M, Faghihinia J, Kelishadi R, Reisi M, Mirlohi S, Pajhang F Indian J Pediatr. 2015; 82(9):794-8.

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