Genes Misregulated in C. Elegans Deficient in Dicer, RDE-4, or RDE-1 Are Enriched for Innate Immunity Genes

Overview

Journal RNA

Specialty Molecular Biology

Date 2007 May 29

PMID 17526642

Citations 38

Authors

Noah C Welker

Jeffrey W Habig

Brenda L Bass

Affiliations

Soon will be listed here.

Abstract

We describe the first microarray analysis of a whole animal containing a mutation in the Dicer gene. We used adult Caenorhabditis elegans and, to distinguish among different roles of Dicer, we also performed microarray analyses of animals with mutations in rde-4 and rde-1, which are involved in silencing by siRNA, but not miRNA. Surprisingly, we find that the X chromosome is greatly enriched for genes regulated by Dicer. Comparison of all three microarray data sets indicates the majority of Dicer-regulated genes are not dependent on RDE-4 or RDE-1, including the X-linked genes. However, all three data sets are enriched in genes important for innate immunity and, specifically, show increased expression of innate immunity genes.

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