[Photodynamic Therapy of Cutaneous Epithelial Malignancies. An Evidence-based Review]

Overview

Journal Hautarzt

Specialty Dermatology

Date 2007 May 25

PMID 17522831

Citations 1

Authors

A Sidoroff

Affiliations

Soon will be listed here.

Abstract

During the last years photodynamic therapy (PDT) has progressively established itself as a standard treatment for non-melanoma skin cancer. A number of clinical studies have demonstrated its efficacy--also compared to other treatment modalities--as well as good acceptance by patients and outstanding cosmetic results. For Bowen disease and superficial basal cell carcinoma, PDT can be regarded as the first-line non-invasive treatment. In the treatment of actinic keratoses PDT should be considered when cosmesis is crucial or in cases of field cancerization. In nodular basal cell carcinoma, effectiveness for lesions up to a thickness of 2 mm is well documented. In summary the evidence level seems sufficient to regard PDT as valuable treatment modality of which patients should not be deprived.

Citing Articles

[Skin tumours of the facial area].

Braun-Falco M HNO. 2009; 57(4):302-14.

PMID: 19322550 DOI: 10.1007/s00106-009-1891-6.

References

Goldman M, Atkin D . ALA/PDT in the treatment of actinic keratosis: spot versus confluent therapy. J Cosmet Laser Ther. 2003; 5(2):107-10. DOI: 10.1080/14769170310001267. View

Calzavara-Pinton P . Repetitive photodynamic therapy with topical delta-aminolaevulinic acid as an appropriate approach to the routine treatment of superficial non-melanoma skin tumours. J Photochem Photobiol B. 1995; 29(1):53-7. DOI: 10.1016/1011-1344(95)90253-8. View

Soler A, Warloe T, Berner A, Giercksky K . A follow-up study of recurrence and cosmesis in completely responding superficial and nodular basal cell carcinomas treated with methyl 5-aminolaevulinate-based photodynamic therapy alone and with prior curettage. Br J Dermatol. 2001; 145(3):467-71. DOI: 10.1046/j.1365-2133.2001.04407.x. View

Jeffes E . Levulan: the first approved topical photosensitizer for the treatment of actinic keratosis. J Dermatolog Treat. 2002; 13 Suppl 1:S19-23. DOI: 10.1080/095466302317414663. View

Kurwa H, Seed P, Markey A, Barlow R . A randomized paired comparison of photodynamic therapy and topical 5-fluorouracil in the treatment of actinic keratoses. J Am Acad Dermatol. 1999; 41(3 Pt 1):414-8. DOI: 10.1016/s0190-9622(99)70114-3. View

Soler A, Warloe T, Tausjo J, Berner A . Photodynamic therapy by topical aminolevulinic acid, dimethylsulphoxide and curettage in nodular basal cell carcinoma: a one-year follow-up study. Acta Derm Venereol. 1999; 79(3):204-6. DOI: 10.1080/000155599750010977. View

Morton C, Horn M, Leman J, Tack B, Bedane C, Tjioe M . Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or Fluorouracil for treatment of squamous cell carcinoma in situ: Results of a multicenter randomized trial. Arch Dermatol. 2006; 142(6):729-35. DOI: 10.1001/archderm.142.6.729. View

Morton C, Brown S, Collins S, Ibbotson S, Jenkinson H, Kurwa H . Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group. Br J Dermatol. 2002; 146(4):552-67. DOI: 10.1046/j.1365-2133.2002.04719.x. View

Szeimies R, Karrer S, Radakovic-Fijan S, Tanew A, Calzavara-Pinton P, Zane C . Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study. J Am Acad Dermatol. 2002; 47(2):258-62. View

10.

Fink-Puches R, Soyer H, Hofer A, Kerl H, Wolf P . Long-term follow-up and histological changes of superficial nonmelanoma skin cancers treated with topical delta-aminolevulinic acid photodynamic therapy. Arch Dermatol. 1998; 134(7):821-6. DOI: 10.1001/archderm.134.7.821. View

11.

Szeimies R, Morton C, Sidoroff A, Braathen L . Photodynamic therapy for non-melanoma skin cancer. Acta Derm Venereol. 2006; 85(6):483-90. DOI: 10.1080/00015550510044136. View

12.

Pariser D, Lowe N, Stewart D, Jarratt M, Lucky A, Pariser R . Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: results of a prospective randomized multicenter trial. J Am Acad Dermatol. 2003; 48(2):227-32. DOI: 10.1067/mjd.2003.49. View

13.

Touma D, Yaar M, Whitehead S, Konnikov N, Gilchrest B . A trial of short incubation, broad-area photodynamic therapy for facial actinic keratoses and diffuse photodamage. Arch Dermatol. 2004; 140(1):33-40. DOI: 10.1001/archderm.140.1.33. View

14.

Fijan S, Honigsmann H, Ortel B . Photodynamic therapy of epithelial skin tumours using delta-aminolaevulinic acid and desferrioxamine. Br J Dermatol. 1995; 133(2):282-8. DOI: 10.1111/j.1365-2133.1995.tb02630.x. View

15.

Wennberg A, Lindholm L, Alpsten M, Larko O . Treatment of superficial basal cell carcinomas using topically applied delta-aminolaevulinic acid and a filtered xenon lamp. Arch Dermatol Res. 1996; 288(10):561-4. DOI: 10.1007/BF02505256. View

16.

Svanberg K, Andersson T, KILLANDER D, Wang I, Stenram U, Andersson-Engels S . Photodynamic therapy of non-melanoma malignant tumours of the skin using topical delta-amino levulinic acid sensitization and laser irradiation. Br J Dermatol. 1994; 130(6):743-51. DOI: 10.1111/j.1365-2133.1994.tb03412.x. View

17.

Thissen M, Schroeter C, Neumann H . Photodynamic therapy with delta-aminolaevulinic acid for nodular basal cell carcinomas using a prior debulking technique. Br J Dermatol. 2000; 142(2):338-9. DOI: 10.1046/j.1365-2133.2000.03404.x. View

18.

Lehmann P . Methyl aminolaevulinate-photodynamic therapy: a review of clinical trials in the treatment of actinic keratoses and nonmelanoma skin cancer. Br J Dermatol. 2007; 156(5):793-801. DOI: 10.1111/j.1365-2133.2007.07833.x. View

19.

Rhodes L, de Rie M, Enstrom Y, Groves R, Morken T, Goulden V . Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial. Arch Dermatol. 2004; 140(1):17-23. DOI: 10.1001/archderm.140.1.17. View

20.

Freeman M, Vinciullo C, Francis D, Spelman L, Nguyen R, Fergin P . A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study. J Dermatolog Treat. 2003; 14(2):99-106. DOI: 10.1080/09546630310012118. View