Ventricular Function During the Acute Rejection of Heterotopic Transplanted Heart: Gated Blood-pool Studies

Overview

Journal Eur J Nucl Med

Specialty Nuclear Medicine

Date 1991 Jan 1

PMID 1752260

Authors

H Valette

M H Bourguignon

M Desruennes

P Merlet

D Le Guludec

M C Gregoire

D Agostini

M Rigaud

I Gandjbakhch

A CABROL

Affiliations

Soon will be listed here.

Abstract

Twenty patients who had undergone a heterotopic heart transplant were studied prospectively to determine the relationship between rejection and ventricular dysfunction assessed from gated blood-pool studies. A fully automated method for detecting ventricular edges was implemented; its success rate for the grafted left and right ventricles was 94% and 77%, respectively. The parameters, peak ejection and filling rates, were calculated pixel per pixel using a two-harmonic Fourier algorithm and then averaged over the ventricular region of interest. Peak filling and ejection rates were closely related with the severity of the rejection, while the left ventricular ejection fraction was not. Peak filling rates of both ventricles were the indices closely related to the presence of moderate rejection. Despite the low number of patients, these data suggested that gated blood-pool-derived indices of ventricular function are associated with ventricular dysfunction resulting from myocarditis rejection. Radionuclide ventriculography provides parametric data which are accurate and reliable for the diagnosis of rejection.

References

Stinson E, Tecklenberg P, Hollingsworth J, Jones K, Sloane R, Rahmoeller G . Changes in left ventricular mechanical and hemodynamic function during acute rejection of orthotopically transplanted hearts in dogs. J Thorac Cardiovasc Surg. 1974; 68(5):783-91. View

Goris M, McKillop J, Briandet P . A fully automated determination of the left ventricular region of interest in nuclear angiocardiography. Cardiovasc Intervent Radiol. 1981; 4(2):117-23. DOI: 10.1007/BF02552390. View

Desruennes M, Corcos T, CABROL A, Gandjbakhch I, Pavie A, Leger P . Doppler echocardiography for the diagnosis of acute cardiac allograft rejection. J Am Coll Cardiol. 1988; 12(1):63-70. DOI: 10.1016/0735-1097(88)90357-9. View

Popp R, Schroeder J, Stinson E, Shumway N, Harrison D . Ultrasonic studies for the early detection of acute cardiac rejection. Transplantation. 1971; 11(6):543-50. View

Iturralde M, Novitzky D, Cooper D, Rose A, Boniaszczuk J, Smith J . The role of nuclear cardiology procedures in the evaluation of cardiac function following heart transplantation. Semin Nucl Med. 1988; 18(3):221-40. DOI: 10.1016/s0001-2998(88)80030-8. View

Machac J, Horowitz S, Broder D, Goldsmith S . Accuracy and precision of regional multiharmonic Fourier analysis of gated blood-pool images. J Nucl Med. 1984; 25(12):1294-9. View

Valette H, Bourguignon M, Douglass K, Del Buono A, Merlet P, Buchanan J . Automatic drawing of the left epicardial region of interest on thallium 201 scintigraphic images. Eur J Nucl Med. 1988; 14(9-10):485-8. DOI: 10.1007/BF00252393. View

Bacharach S, Green M, Borer J, Hyde J, Farkas S, Johnston G . Left-ventricular peak ejection rate, filling rate, and ejection fraction--frame rate requirements at rest and exercise: concise communication. J Nucl Med. 2013; 20(3):189-93. View

Hansen D, Daughters 2nd G, Alderman E, Stinson E, Baldwin J, Miller D . Effect of acute human cardiac allograft rejection on left ventricular systolic torsion and diastolic recoil measured by intramyocardial markers. Circulation. 1987; 76(5):998-1008. DOI: 10.1161/01.cir.76.5.998. View

10.

Bonow R, Bacharach S, Green M, Kent K, Rosing D, Lipson L . Impaired left ventricular diastolic filling in patients with coronary artery disease: assessment with radionuclide angiography. Circulation. 1981; 64(2):315-23. DOI: 10.1161/01.cir.64.2.315. View

11.

Paulsen W, MAGID N, Sagar K, Hastillo A, Wolfgang T, LOWER R . Left ventricular function of heart allografts during acute rejection: an echocardiographic assessment. J Heart Transplant. 1985; 4(5):525-9. View

12.

Valette H, Bourguignon M, Apoil E, Moyse D, Wise R, Buchanan J . Accuracy of gated equilibrium radioventriculography in measuring left ventricular function in dogs. Nucl Med Commun. 1988; 9(12):999-1004. DOI: 10.1097/00006231-198812000-00009. View

13.

Zatta G, Tarolo G, Palagi B, Picozzi R, Albertini A, Zoccarato O . Computerized analysis of equilibrium radionuclide ventriculography time-activity curve in the assessment of left ventricular performance: comparison of two methods. Eur J Nucl Med. 1985; 10(5-6):198-202. DOI: 10.1007/BF00254461. View

14.

Freeman M, Stevens K, BARNES W, Palac R, Eastman G, Subramanian K . Regional diastolic functional images utilizing time-domain analysis of gated radionuclide ventriculograms. Am Heart J. 1985; 109(4):890-9. DOI: 10.1016/0002-8703(85)90655-6. View

15.

Lee K, Wallis J, Miller T, Bolman 3rd R . The clinical utility of radionuclide ventriculography in cardiac transplantation. J Nucl Med. 1990; 31(12):1933-9. View

16.

Shaffer P, Magorien D, Olsen J, Bashore T . Failure of normalized ventricular filling rates to predict true filling rates. Nucl Med Commun. 1987; 8(6):417-29. DOI: 10.1097/00006231-198706000-00004. View

17.

Dietz R, Patton D, Copeland J, McNeill G . Characteristics of the transplanted heart in the radionuclide ventriculogram. J Heart Transplant. 1986; 5(2):113-21. View

18.

McGiffin D, Karp R, Logic J, TAUXE W, Ceballos R . Results of radionuclide assessment of cardiac function following transplantation of the heart. Ann Thorac Surg. 1984; 37(5):382-6. DOI: 10.1016/s0003-4975(10)60759-x. View

19.

Lee B, Goodenday L, Muswick G, Yasnoff W, Leighton R, Skeel R . Alterations in left ventricular diastolic function with doxorubicin therapy. J Am Coll Cardiol. 1987; 9(1):184-8. DOI: 10.1016/s0735-1097(87)80099-2. View

20.

Inouye I, Massie B, Loge D, Topic N, Silverstein D, Simpson P . Abnormal left ventricular filling: an early finding in mild to moderate systemic hypertension. Am J Cardiol. 1984; 53(1):120-6. DOI: 10.1016/0002-9149(84)90695-7. View