Characterization of Zinc Finger Protein 496 That Interacts with Jumonji/Jarid2

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2007 May 25

PMID 17521633

Citations 14

Authors

Matthew Robert Mysliwiec

Tae-Gyun Kim

Youngsook Lee

Affiliations

Soon will be listed here.

Abstract

Jumonij (JMJ)/Jarid2 plays important roles in embryonic development and functions as a transcriptional repressor. Using yeast two-hybrid screening, we have identified a cofactor of JMJ, the zinc finger protein 496 (Zfp496) that contains a SCAN, KRAB and zinc finger domain. Our molecular analyses indicate that Zfp496 functions as a transcriptional activator. Further, Zfp496 inhibits the transcriptional repression of JMJ and JMJ represses the transcriptional activation of Zfp496. This study demonstrates that JMJ physically and functionally interacts with Zfp496, which will provide important insights into endogenous target gene regulation by both factors.

Citing Articles

DUF3669, a "domain of unknown function" within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression.

Al Chiblak M, Steinbeck F, Thiesen H, Lorenz P BMC Mol Cell Biol. 2019; 20(1):60.

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Common and distinct transcriptional signatures of mammalian embryonic lethality.

Collins J, White R, Staudt N, Sealy I, Packham I, Wali N Nat Commun. 2019; 10(1):2792.

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Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.

Cho E, Mysliwiec M, Carlson C, Ansari A, Schwartz R, Lee Y J Biol Chem. 2018; 293(30):11659-11673.

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PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula.

Mikedis M, Downs K Dev Dyn. 2016; 246(1):50-71.

PMID: 27696611 PMC: 5159262. DOI: 10.1002/dvdy.24461.

The Transcriptional Repressive Activity of KRAB Zinc Finger Proteins Does Not Correlate with Their Ability to Recruit TRIM28.

Murphy K, Shylo N, Alexander K, Churchill A, Copperman C, Garcia-Garcia M PLoS One. 2016; 11(9):e0163555.

PMID: 27658112 PMC: 5033580. DOI: 10.1371/journal.pone.0163555.

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