Regulation of Innate Immune Response by MAP Kinase Phosphatase-1

Overview

Journal Cell Signal

Date 2007 May 22

PMID 17512700

Citations 72

Authors

Xianxi Wang

Yusen Liu

Affiliations

Soon will be listed here.

Abstract

Mitogen-activated protein (MAP) kinase cascades are signal transduction pathways that play pivotal regulatory roles in the biosynthesis of pro-inflammatory cytokines. MAP kinase phosphatase (MKP)-1, an archetypal member of the MKP family, is essential for the dephosphorylation/deactivation of MAP kinases p38 and JNK. Earlier studies conducted using cultured immortalized macrophages provided compelling evidence indicating that MKP-1 deactivates p38 and JNK, thereby limiting pro-inflammatory cytokine biosynthesis in innate immune cells exposed to microbial components. Recent studies employing MKP-1 knockout mice have confirmed the central function of MKP-1 in the feedback control of p38 and JNK activity as well as the crucial physiological function of MKP-1 as a negative regulator of the synthesis of pro-inflammatory cytokines in vivo. MKP-1 was shown to be a major feedback regulator of the innate immune response and to play a critical role in preventing septic shock and multi-organ dysfunction during pathogenic infection. In this review, we will update the studies on the biochemical properties and the regulation of MKP-1, and summarize our understanding on the physiological function of this key phosphatase in the innate immune response.

Citing Articles

Hepatocyte-specific mitogen-activated protein kinase phosphatase 1 in sexual dimorphism and susceptibility to alcohol induced liver injury.

Walter M, Montoya-Durango D, Rodriguez W, Wang Y, Zhang J, Chariker J Front Immunol. 2024; 15:1316228.

PMID: 38370409 PMC: 10871047. DOI: 10.3389/fimmu.2024.1316228.

5-Hydroxymethylfurfural Ameliorates Allergic Inflammation in HMC-1 Cells by Inactivating NF-κB and MAPK Signaling Pathways.

Hu P, Zhang Z, Yu X, Wang Y Biochem Genet. 2023; 62(3):1521-1538.

PMID: 37648883 DOI: 10.1007/s10528-023-10492-9.

Network pharmacology-based analysis and experimental in vitro validation on the mechanism of Paeonia lactiflora Pall. in the treatment for type I allergy.

Zhao Y, Li H, Li X, Sun Y, Shao Y, Zhang Y BMC Complement Med Ther. 2022; 22(1):199.

PMID: 35879791 PMC: 9317138. DOI: 10.1186/s12906-022-03677-z.

The MAP Kinase Phosphatase MKP-1 Modulates Neurogenesis via Effects on BNIP3 and Autophagy.

Li Y, Halterman M Biomolecules. 2021; 11(12).

PMID: 34944516 PMC: 8699509. DOI: 10.3390/biom11121871.

Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial Dysfunction.

Akbar N, Forteath C, Hussain M, Reyskens K, Belch J, Lang C Int J Mol Sci. 2021; 22(16).

PMID: 34445361 PMC: 8395442. DOI: 10.3390/ijms22168655.

References

Sanchez-Tillo E, Comalada M, Farrera C, Valledor A, Lloberas J, Celada A . Macrophage-colony-stimulating factor-induced proliferation and lipopolysaccharide-dependent activation of macrophages requires Raf-1 phosphorylation to induce mitogen kinase phosphatase-1 expression. J Immunol. 2006; 176(11):6594-602. DOI: 10.4049/jimmunol.176.11.6594. View

Kwak S, Hakes D, Martell K, Dixon J . Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene. J Biol Chem. 1994; 269(5):3596-604. View

Franklin C, Kraft A . Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells. J Biol Chem. 1997; 272(27):16917-23. DOI: 10.1074/jbc.272.27.16917. View

Liao Q, Guo J, Kleeff J, Zimmermann A, Buchler M, Korc M . Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumorigenicity of pancreatic cancer cells. Gastroenterology. 2003; 124(7):1830-45. DOI: 10.1016/s0016-5085(03)00398-6. View

Nishida E, Gotoh Y . The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci. 1993; 18(4):128-31. DOI: 10.1016/0968-0004(93)90019-j. View

Schwan W, Kugler S, Schuller S, Kopecko D, Goebel W . Detection and characterization by differential PCR of host eukaryotic cell genes differentially transcribed following uptake of intracellular bacteria. Infect Immun. 1996; 64(1):91-9. PMC: 173732. DOI: 10.1128/iai.64.1.91-99.1996. View

Beutler B, Kruys V . Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself. J Cardiovasc Pharmacol. 1995; 25 Suppl 2:S1-8. DOI: 10.1097/00005344-199500252-00002. View

Roger T, David J, Glauser M, Calandra T . MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature. 2002; 414(6866):920-4. DOI: 10.1038/414920a. View

Han J, Thompson P, Beutler B . Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. J Exp Med. 1990; 172(1):391-4. PMC: 2188134. DOI: 10.1084/jem.172.1.391. View

10.

Raingeaud J, Gupta S, Rogers J, Dickens M, Han J, Ulevitch R . Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem. 1995; 270(13):7420-6. DOI: 10.1074/jbc.270.13.7420. View

11.

Stewart A, Dowd S, Keyse S, McDonald N . Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation. Nat Struct Biol. 1999; 6(2):174-81. DOI: 10.1038/5861. View

12.

Whitmarsh A, Davis R . Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med (Berl). 1996; 74(10):589-607. DOI: 10.1007/s001090050063. View

13.

Hambleton J, McMahon M, DeFranco A . Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events. J Exp Med. 1995; 182(1):147-54. PMC: 2192101. DOI: 10.1084/jem.182.1.147. View

14.

Salojin K, Owusu I, Millerchip K, Potter M, Platt K, Oravecz T . Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J Immunol. 2006; 176(3):1899-907. DOI: 10.4049/jimmunol.176.3.1899. View

15.

Bhalla U, Ram P, Iyengar R . MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science. 2002; 297(5583):1018-23. DOI: 10.1126/science.1068873. View

16.

Gordon S . The macrophage. Bioessays. 1995; 17(11):977-86. DOI: 10.1002/bies.950171111. View

17.

Shepherd E, Zhao Q, Welty S, Hansen T, Smith C, Liu Y . The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages. J Biol Chem. 2004; 279(52):54023-31. DOI: 10.1074/jbc.M408444200. View

18.

Zheng C, Guan K . Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase. J Biol Chem. 1993; 268(22):16116-9. View

19.

Singleton K, Beckey V, Wischmeyer P . GLUTAMINE PREVENTS ACTIVATION OF NF-kappaB AND STRESS KINASE PATHWAYS, ATTENUATES INFLAMMATORY CYTOKINE RELEASE, AND PREVENTS ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) FOLLOWING SEPSIS. Shock. 2005; 24(6):583-9. DOI: 10.1097/01.shk.0000185795.96964.71. View

20.

Brondello J, Pouyssegur J, McKenzie F . Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science. 2000; 286(5449):2514-7. DOI: 10.1126/science.286.5449.2514. View