Contribution of Polymorphisms in AnkA, GltA, and GroESL in Defining Genetic Variants of Anaplasma Phagocytophilum

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2007 May 18

PMID 17507511

Citations 5

Authors

Sanjay K Shukla

Vijay Aswani

Patrick J Stockwell

Kurt D Reed

Affiliations

Soon will be listed here.

Abstract

Analysis of several nucleotide polymorphisms in polymorphic genes (ankA, gltA, and groESL) from 16S rRNA gene-based genetic variants of Anaplasma phagocytophilum from dogs in the western United States defined at least two sets of multigene polymorphisms to further characterize these variants. The multigene polymorphism approach holds promise for development of a genotyping scheme for this important pathogen.

Citing Articles

A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe.

Matei I, Estrada-Pena A, Cutler S, Vayssier-Taussat M, Varela-Castro L, Potkonjak A Parasit Vectors. 2019; 12(1):599.

PMID: 31864403 PMC: 6925858. DOI: 10.1186/s13071-019-3852-6.

Detecting and characterizing mixed infections with genetic variants of Anaplasma phagocytophilum in roe deer (Capreolus capreolus) by developing an ankA cluster-specific nested PCR.

Jouglin M, Chagneau S, Faille F, Verheyden H, Bastian S, Malandrin L Parasit Vectors. 2017; 10(1):377.

PMID: 28784148 PMC: 5547487. DOI: 10.1186/s13071-017-2316-0.

A new multiple-locus variable-number tandem repeat analysis reveals different clusters for Anaplasma phagocytophilum circulating in domestic and wild ruminants.

Dugat T, Chastagner A, Lagree A, Petit E, Durand B, Thierry S Parasit Vectors. 2014; 7:439.

PMID: 25228371 PMC: 4262125. DOI: 10.1186/1756-3305-7-439.

SNUFER: A software for localization and presentation of single nucleotide polymorphisms using a Clustal multiple sequence alignment output file.

Mansur M, Cardozo G, Santos E, Marins M Bioinformation. 2009; 3(2):63-4.

PMID: 19238196 PMC: 2639674. DOI: 10.6026/97320630003063.

Dynamic transmission of numerous Anaplasma phagocytophilum genotypes among lambs in an infected sheep flock in an area of anaplasmosis endemicity.

Ladbury G, Stuen S, Thomas R, Bown K, Woldehiwet Z, Granquist E J Clin Microbiol. 2008; 46(5):1686-91.

PMID: 18367562 PMC: 2395098. DOI: 10.1128/JCM.02068-07.

References

Roux V, Rydkina E, Eremeeva M, Raoult D . Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae. Int J Syst Bacteriol. 1997; 47(2):252-61. DOI: 10.1099/00207713-47-2-252. View

Poitout F, Shinozaki J, Stockwell P, Holland C, Shukla S . Genetic variants of Anaplasma phagocytophilum infecting dogs in Western Washington State. J Clin Microbiol. 2005; 43(2):796-801. PMC: 548079. DOI: 10.1128/JCM.43.2.796-801.2005. View

Sumner J, Nicholson W, Massung R . PCR amplification and comparison of nucleotide sequences from the groESL heat shock operon of Ehrlichia species. J Clin Microbiol. 1997; 35(8):2087-92. PMC: 229908. DOI: 10.1128/jcm.35.8.2087-2092.1997. View

Asanovich K, Bakken J, Madigan J, Aguero-Rosenfeld M, Wormser G, Dumler J . Antigenic diversity of granulocytic Ehrlichia isolates from humans in Wisconsin and New York and a horse in California. J Infect Dis. 1997; 176(4):1029-34. DOI: 10.1086/516529. View

Alberti A, Zobba R, Chessa B, Addis M, Sparagano O, Pinna Parpaglia M . Equine and canine Anaplasma phagocytophilum strains isolated on the island of Sardinia (Italy) are phylogenetically related to pathogenic strains from the United States. Appl Environ Microbiol. 2005; 71(10):6418-22. PMC: 1265917. DOI: 10.1128/AEM.71.10.6418-6422.2005. View

Massung R, Mather T, Levin M . Reservoir competency of goats for the Ap-variant 1 strain of Anaplasma phagocytophilum. Infect Immun. 2006; 74(2):1373-5. PMC: 1360349. DOI: 10.1128/IAI.74.2.1373-1375.2006. View

Hall B, Barlow M . Phylogenetic analysis as a tool in molecular epidemiology of infectious diseases. Ann Epidemiol. 2005; 16(3):157-69. DOI: 10.1016/j.annepidem.2005.04.010. View

Dunning Hotopp J, Lin M, Madupu R, Crabtree J, Angiuoli S, Eisen J . Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet. 2006; 2(2):e21. PMC: 1366493. DOI: 10.1371/journal.pgen.0020021. View

Bjoersdorff A, Berglund J, Kristiansen B, Soderstrom C, Eliasson I . [Varying clinical picture and course of human granulocytic ehrlichiosis. Twelve Scandinavian cases of the new tick-borne zoonosis are presented]. Lakartidningen. 1999; 96(39):4200-4. View

10.

WALLS J, Caturegli P, Bakken J, Asanovich K, Dumler J . Improved sensitivity of PCR for diagnosis of human granulocytic ehrlichiosis using epank1 genes of Ehrlichia phagocytophila-group ehrlichiae. J Clin Microbiol. 2000; 38(1):354-6. PMC: 88723. DOI: 10.1128/JCM.38.1.354-356.2000. View

11.

Chae J, Foley J, Dumler J, Madigan J . Comparison of the nucleotide sequences of 16S rRNA, 444 Ep-ank, and groESL heat shock operon genes in naturally occurring Ehrlichia equi and human granulocytic ehrlichiosis agent isolates from Northern California. J Clin Microbiol. 2000; 38(4):1364-9. PMC: 86446. DOI: 10.1128/JCM.38.4.1364-1369.2000. View

12.

Sumner J, Storch G, Buller R, Liddell A, Stockham S, Rikihisa Y . PCR amplification and phylogenetic analysis of groESL operon sequences from Ehrlichia ewingii and Ehrlichia muris. J Clin Microbiol. 2000; 38(7):2746-9. PMC: 87017. DOI: 10.1128/JCM.38.7.2746-2749.2000. View

13.

Massung R, Owens J, Ross D, Reed K, Petrovec M, Bjoersdorff A . Sequence analysis of the ank gene of granulocytic ehrlichiae. J Clin Microbiol. 2000; 38(8):2917-22. PMC: 87147. DOI: 10.1128/JCM.38.8.2917-2922.2000. View

14.

Pusterla N, Chang C, Chomel B, Chae J, Foley J, DeRock E . Serologic and molecular evidence of Ehrlichia spp. in coyotes in California. J Wildl Dis. 2000; 36(3):494-9. DOI: 10.7589/0090-3558-36.3.494. View

15.

Caturegli P, Asanovich K, WALLS J, Bakken J, Madigan J, Popov V . ankA: an Ehrlichia phagocytophila group gene encoding a cytoplasmic protein antigen with ankyrin repeats. Infect Immun. 2000; 68(9):5277-83. PMC: 101789. DOI: 10.1128/IAI.68.9.5277-5283.2000. View

16.

Weber R, Pusterla N, Loy M, Leutenegger C, Schar G, Baumann D . [Serologic and clinical evidence for endemic occurrences of human granulocytic ehrlichiosis in North-Eastern Switzerland]. Schweiz Med Wochenschr. 2000; 130(41):1462-70. View

17.

Inokuma H, Brouqui P, Drancourt M, Raoult D . Citrate synthase gene sequence: a new tool for phylogenetic analysis and identification of Ehrlichia. J Clin Microbiol. 2001; 39(9):3031-9. PMC: 88292. DOI: 10.1128/JCM.39.9.3031-3039.2001. View

18.

Lotric-Furlan S, Avsic-Zupanc T, Petrovec M, Nicholson W, Sumner J, Childs J . Clinical and serological follow-up of patients with human granulocytic ehrlichiosis in Slovenia. Clin Diagn Lab Immunol. 2001; 8(5):899-903. PMC: 96168. DOI: 10.1128/CDLI.8.5.899-903.2001. View

19.

Bjoersdorff A, Bagert B, Massung R, Gusa A, Eliasson I . Isolation and characterization of two European strains of Ehrlichia phagocytophila of equine origin. Clin Diagn Lab Immunol. 2002; 9(2):341-3. PMC: 119922. DOI: 10.1128/cdli.9.2.341-343.2002. View

20.

Massung R, Mauel M, Owens J, Allan N, Courtney J, Stafford 3rd K . Genetic variants of Ehrlichia phagocytophila, Rhode Island and Connecticut. Emerg Infect Dis. 2002; 8(5):467-72. PMC: 3369764. DOI: 10.3201/eid0805.010251. View