Personality Traits in Unaffected Twins Discordant for Affective Disorder

Overview

Journal Acta Psychiatr Scand

Specialty Psychiatry

Date 2007 May 15

PMID 17498155

Citations 5

Authors

M Vinberg

E L Mortensen

K O Kyvik

L V Kessing

Affiliations

Soon will be listed here.

Abstract

Objective: To examine whether a high genetic liability to develop affective disorder is associated with specific personality traits.

Method: A cross-sectional, high-risk, case-control study. Through nation-wide registers, healthy monozygotic (MZ) and dizygotic (DZ) twins with (high-risk twins) and without (the control group/low-risk twins) a co-twin history of affective disorder were identified. Personality traits were compared for a total of 211 high-risk and low-risk twins.

Results: In univariate analyses, the high-risk twins had a higher level of neuroticism than the control twins (P = 0.03). In multivariate analyses, a high genetic liability to affective disorder was not significantly associated with neuroticism but correlated to sex, minor psychopathology and recent life events.

Conclusion: A high genetic liability to affective disorder showed an association with neuroticism, but the association interacts with other predictors of affective disorder such as female gender, minor psychopathology and recent adversity.

Citing Articles

The Validity of Daily Self-Assessed Perceived Stress Measured Using Smartphones in Healthy Individuals: Cohort Study.

Borarinsdottir H, Faurholt-Jepsen M, Ullum H, Frost M, Bardram J, Kessing L JMIR Mhealth Uhealth. 2019; 7(8):e13418.

PMID: 31429413 PMC: 6718079. DOI: 10.2196/13418.

Clinical Characteristics, Life Adversities and Personality Traits in Monozygotic Twins With, at Risk of and Without Affective Disorders.

Ottesen N, Meluken I, Scheike T, Kessing L, Miskowiak K, Vinberg M Front Psychiatry. 2018; 9:401.

PMID: 30233425 PMC: 6127629. DOI: 10.3389/fpsyt.2018.00401.

DNA modification study of major depressive disorder: beyond locus-by-locus comparisons.

Oh G, Wang S, Pal M, Chen Z, Khare T, Tochigi M Biol Psychiatry. 2014; 77(3):246-255.

PMID: 25108803 PMC: 4277915. DOI: 10.1016/j.biopsych.2014.06.016.

Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding.

Frokjaer V, Vinberg M, Erritzoe D, Baare W, Holst K, Mortensen E Neuropsychopharmacology. 2010; 35(5):1129-37.

PMID: 20043006 PMC: 3055406. DOI: 10.1038/npp.2009.218.

Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram....

Knorr U, Vinberg M, Klose M, Feldt-Rasmussen U, Hilsted L, Gade A Trials. 2009; 10:66.

PMID: 19671139 PMC: 2731751. DOI: 10.1186/1745-6215-10-66.