Is the Sugar Always Sweet in Intestinal Inflammation?

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2007 May 15

PMID 17496346

Citations 9

Authors

Emiko Mizoguchi

Atsushi Mizoguchi

Affiliations

Soon will be listed here.

Abstract

Immune responses are mediated mainly by protein/protein interactions. In addition, protein/carbohydrate (sugar) interactions through specific protein families termed lectin and chi-lectin are also involved in several immune and biological responses under not only the state of health but also inflammatory conditions. Interestingly, recent studies have identified unexpected roles of animal lectins (galectin-1 and galectin-4) and chi-lectin (chitinase 3-like-1) in intestinal inflammation. Galectin-1 contributes to the suppression of intestinal inflammation by the induction of effector T cell apoptosis. In contrast, galectin-4 is involved in the exacerbation of this inflammation by specifically stimulating intestinal CD4+ T cells to produce IL-6. CHI3L1 enhances the host/microbial interaction that leads to the exacerbation of intestinal inflammation. In this review, we discuss a novel aspect of lectin/carbohydrate interactions in intestinal inflammation.

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References

Verhage H, Fazleabas A, Donnelly K . The in vitro synthesis and release of proteins by the human oviduct. Endocrinology. 1988; 122(4):1639-45. DOI: 10.1210/endo-122-4-1639. View

Aronson N, Blanchard C, Madura J . Homology modeling of glycosyl hydrolase family 18 enzymes and proteins. J Chem Inf Comput Sci. 1997; 37(6):999-1005. DOI: 10.1021/ci970236v. View

Swidsinski A, Ladhoff A, Pernthaler A, Swidsinski S, Loening-Baucke V, Ortner M . Mucosal flora in inflammatory bowel disease. Gastroenterology. 2002; 122(1):44-54. DOI: 10.1053/gast.2002.30294. View

Shahabuddin M, Toyoshima T, Aikawa M, Kaslow D . Transmission-blocking activity of a chitinase inhibitor and activation of malarial parasite chitinase by mosquito protease. Proc Natl Acad Sci U S A. 1993; 90(9):4266-70. PMC: 46487. DOI: 10.1073/pnas.90.9.4266. View

Cortegano I, Del Pozo V, Cardaba B, de Andres B, Gallardo S, del Amo A . Galectin-3 down-regulates IL-5 gene expression on different cell types. J Immunol. 1998; 161(1):385-9. View

Saito A, Ozaki K, Fujiwara T, Nakamura Y, Tanigami A . Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member. Gene. 1999; 239(2):325-31. DOI: 10.1016/s0378-1119(99)00394-7. View

Herrera-Estrella A, Chet I . Chitinases in biological control. EXS. 2000; 87:171-84. DOI: 10.1007/978-3-0348-8757-1_12. View

Perillo N, Uittenbogaart C, Nguyen J, Baum L . Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes. J Exp Med. 1997; 185(10):1851-8. PMC: 2196320. DOI: 10.1084/jem.185.10.1851. View

Tjoelker L, Gosting L, Frey S, Hunter C, Trong H, Steiner B . Structural and functional definition of the human chitinase chitin-binding domain. J Biol Chem. 2000; 275(1):514-20. DOI: 10.1074/jbc.275.1.514. View

10.

Mizoguchi A, Bhan A . A case for regulatory B cells. J Immunol. 2006; 176(2):705-10. DOI: 10.4049/jimmunol.176.2.705. View

11.

Podolsky D . Inflammatory bowel disease. N Engl J Med. 2002; 347(6):417-29. DOI: 10.1056/NEJMra020831. View

12.

Rogers N, Slack E, Edwards A, Nolte M, Schulz O, Schweighoffer E . Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity. 2005; 22(4):507-17. DOI: 10.1016/j.immuni.2005.03.004. View

13.

Mizoguchi E . Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells. Gastroenterology. 2006; 130(2):398-411. DOI: 10.1053/j.gastro.2005.12.007. View

14.

Ward J, Yoon M, Anver M, Haines D, Kudo G, Gonzalez F . Hyalinosis and Ym1/Ym2 gene expression in the stomach and respiratory tract of 129S4/SvJae and wild-type and CYP1A2-null B6, 129 mice. Am J Pathol. 2001; 158(1):323-32. PMC: 1850245. DOI: 10.1016/S0002-9440(10)63972-7. View

15.

Rabinovich G, Baum L, Tinari N, Paganelli R, Natoli C, Liu F . Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?. Trends Immunol. 2002; 23(6):313-20. DOI: 10.1016/s1471-4906(02)02232-9. View

16.

Suzuki K, Suzuki M, Taiyoji M, Nikaidou N, Watanabe T . Chitin binding protein (CBP21) in the culture supernatant of Serratia marcescens 2170. Biosci Biotechnol Biochem. 1998; 62(1):128-35. DOI: 10.1271/bbb.62.128. View

17.

Hokama A, Mizoguchi E, Sugimoto K, Shimomura Y, Tanaka Y, Yoshida M . Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Immunity. 2004; 20(6):681-93. DOI: 10.1016/j.immuni.2004.05.009. View

18.

Arias E, Verhage H, Jaffe R . Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. Biol Reprod. 1994; 51(4):685-94. DOI: 10.1095/biolreprod51.4.685. View

19.

Shibata Y, Foster L, Bradfield J, Myrvik Q . Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse. J Immunol. 2000; 164(3):1314-21. DOI: 10.4049/jimmunol.164.3.1314. View

20.

Daniels M, Devine L, Miller J, MOSER J, Lukacher A, Altman J . CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation. Immunity. 2002; 15(6):1051-61. DOI: 10.1016/s1074-7613(01)00252-7. View