Cyclooxygenase Polymorphisms and Risk of Cardiovascular Events: the Atherosclerosis Risk in Communities (ARIC) Study

Overview

Journal Clin Pharmacol Ther

Publisher Wiley

Specialty Pharmacology

Date 2007 May 15

PMID 17495879

Citations 31

Authors

C R Lee

K E North

M S Bray

D J Couper

G Heiss

D C Zeldin

Affiliations

Soon will be listed here.

Abstract

Cyclooxygenase-derived prostaglandins modulate cardiovascular disease risk. We genotyped 2212 Atherosclerosis Risk in Communities study participants (1,023 incident coronary heart disease (CHD) cases; 270 incident ischemic stroke cases; 919 non-cases) with available DNA for polymorphisms in PTGS1 and PTGS2. Using a case-cohort design, associations between genotype and CHD or stroke risk were evaluated using proportional hazards regression. In Caucasians, the reduced function PTGS1 -1006A variant allele was significantly more common among stroke cases compared to non-cases (18.2 versus 10.6%, P=0.027). In African Americans, the reduced function PTGS2 -765C variant allele was significantly more common in stroke cases (61.4 versus 49.4%, P=0.032). No significant relationships with CHD risk were observed. However, aspirin utilization appeared to modify the relationship between the PTGS2 G-765C polymorphism and CHD risk (interaction P=0.072). These findings suggest that genetic variation in PTGS1 and PTGS2 may be important risk factors for the development of cardiovascular disease events. Confirmation in independent populations is necessary.

Citing Articles

Efficient estimation for left-truncated competing risks regression for case-cohort studies.

Fang X, Ahn K, Cai J, Kim S Biometrics. 2024; 80(1).

PMID: 38281769 PMC: 10826882. DOI: 10.1093/biomtc/ujad008.

Prostanoids in Cardiac and Vascular Remodeling.

Ricciotti E, Haines P, Chai W, FitzGerald G Arterioscler Thromb Vasc Biol. 2024; 44(3):558-583.

PMID: 38269585 PMC: 10922399. DOI: 10.1161/ATVBAHA.123.320045.

The Link between Prostanoids and Cardiovascular Diseases.

Beccacece L, Abondio P, Bini C, Pelotti S, Luiselli D Int J Mol Sci. 2023; 24(4).

PMID: 36835616 PMC: 9962914. DOI: 10.3390/ijms24044193.

Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of the Gene: A Cross-Sectional Analysis of Shika Study.

Pham K, Hara A, Tsujiguchi H, Suzuki K, Suzuki F, Miyagi S Nutrients. 2022; 14(10).

PMID: 35631221 PMC: 9143472. DOI: 10.3390/nu14102082.

Construction and Bioinformatics Analysis of circRNA-miRNA-mRNA Network in Acute Myocardial Infarction.

Zhou J, He S, Wang B, Yang W, Zheng Y, Jiang S Front Genet. 2022; 13:854993.

PMID: 35422846 PMC: 9002054. DOI: 10.3389/fgene.2022.854993.

References

Barlow W, Ichikawa L, ROSNER D, Izumi S . Analysis of case-cohort designs. J Clin Epidemiol. 1999; 52(12):1165-72. DOI: 10.1016/s0895-4356(99)00102-x. View

Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E . Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc Natl Acad Sci U S A. 2001; 98(3):1294-9. PMC: 14748. DOI: 10.1073/pnas.98.3.1294. View

Li R, Folsom A, Sharrett A, Couper D, Bray M, Tyroler H . Interaction of the glutathione S-transferase genes and cigarette smoking on risk of lower extremity arterial disease: the Atherosclerosis Risk in Communities (ARIC) study. Atherosclerosis. 2001; 154(3):729-38. DOI: 10.1016/s0021-9150(00)00582-7. View

Niwa K, Haensel C, Ross M, Iadecola C . Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation. Circ Res. 2001; 88(6):600-8. DOI: 10.1161/01.res.88.6.600. View

Bray M, Boerwinkle E, Doris P . High-throughput multiplex SNP genotyping with MALDI-TOF mass spectrometry: practice, problems and promise. Hum Mutat. 2001; 17(4):296-304. DOI: 10.1002/humu.27. View

Brian Jr J, Faraci F, Moore S . COX-2-dependent delayed dilatation of cerebral arterioles in response to bradykinin. Am J Physiol Heart Circ Physiol. 2001; 280(5):H2023-9. DOI: 10.1152/ajpheart.2001.280.5.H2023. View

Davidge S . Prostaglandin H synthase and vascular function. Circ Res. 2001; 89(8):650-60. DOI: 10.1161/hh2001.098351. View

Fritsche E, Baek S, King L, Zeldin D, Eling T, Bell D . Functional characterization of cyclooxygenase-2 polymorphisms. J Pharmacol Exp Ther. 2001; 299(2):468-76. View

Camitta M, Gabel S, Chulada P, Bradbury J, Langenbach R, Zeldin D . Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning. Circulation. 2001; 104(20):2453-8. DOI: 10.1161/hc4401.098429. View

10.

Iadecola C, Sugimoto K, Niwa K, Kazama K, Ross M . Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice. J Cereb Blood Flow Metab. 2001; 21(12):1436-41. DOI: 10.1097/00004647-200112000-00008. View

11.

Lin H, Lin T, Cheung W, Tseng P, Chen S, Chen J . Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction. Circulation. 2002; 105(16):1962-9. DOI: 10.1161/01.cir.0000015365.49180.05. View

12.

Papafili A, Hill M, Brull D, McAnulty R, Marshall R, Humphries S . Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. Arterioscler Thromb Vasc Biol. 2002; 22(10):1631-6. DOI: 10.1161/01.atv.0000030340.80207.c5. View

13.

Ulrich C, Bigler J, Sibert J, Greene E, Sparks R, Carlson C . Cyclooxygenase 1 (COX1) polymorphisms in African-American and Caucasian populations. Hum Mutat. 2002; 20(5):409-10. DOI: 10.1002/humu.9080. View

14.

Halushka M, Walker L, Halushka P . Genetic variation in cyclooxygenase 1: effects on response to aspirin. Clin Pharmacol Ther. 2003; 73(1):122-30. DOI: 10.1067/mcp.2003.1. View

15.

Dore S, Otsuka T, Mito T, Sugo N, Hand T, Wu L . Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. Ann Neurol. 2003; 54(2):155-62. DOI: 10.1002/ana.10612. View

16.

Storey J, Tibshirani R . Statistical significance for genomewide studies. Proc Natl Acad Sci U S A. 2003; 100(16):9440-5. PMC: 170937. DOI: 10.1073/pnas.1530509100. View

17.

Cipollone F, Toniato E, Martinotti S, Fazia M, Iezzi A, Cuccurullo C . A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. JAMA. 2004; 291(18):2221-8. DOI: 10.1001/jama.291.18.2221. View

18.

Kobayashi T, Tahara Y, Matsumoto M, Iguchi M, Sano H, Murayama T . Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. J Clin Invest. 2004; 114(6):784-94. PMC: 516261. DOI: 10.1172/JCI21446. View

19.

Barrett J, Fry B, Maller J, Daly M . Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2004; 21(2):263-5. DOI: 10.1093/bioinformatics/bth457. View

20.

Shen R, Fan J, Campbell D, Chang W, Chen J, Doucet D . High-throughput SNP genotyping on universal bead arrays. Mutat Res. 2005; 573(1-2):70-82. DOI: 10.1016/j.mrfmmm.2004.07.022. View