Acute D-amphetamine Pretreatment Does Not Alter Stimulant Self-administration in Humans

Overview

Journal Pharmacol Biochem Behav

Publisher Elsevier

Specialties Biochemistry
Pharmacology
Psychology
Social Sciences

Date 2007 May 11

PMID 17490738

Citations 14

Authors

William W Stoops

Andrea R Vansickel

Joshua A Lile

Craig R Rush

Affiliations

Soon will be listed here.

Abstract

Recent clinical research indicates that d-amphetamine is effective in treating cocaine and methamphetamine dependence. There is concern, however, with the use of d-amphetamine as a pharmacotherapy because acute administration of d-amphetamine decreases inhibition in cocaine-using individuals and may increase drug-taking behavior. The purpose of the present experiment was to determine whether acute d-amphetamine pretreatment would alter the reinforcing, subject-rated, and cardiovascular effects of d-amphetamine. To this end, 7 human volunteers first sampled doses of oral d-amphetamine (0, 8, and 16 mg). These doses engender moderate drug taking and were selected to avoid a ceiling or floor effect. Volunteers were then allowed to self-administer these sampled doses using a modified progressive-ratio procedure in two sessions in which they received pretreatment with either 0 or 15 mg oral d-amphetamine 2 h prior to completing the modified progressive-ratio procedure. d-Amphetamine produced prototypical stimulant-like effects (e.g., increased ratings of stimulated, elevated blood pressure) and maintained responding on the modified progressive-ratio schedule. Pretreatment with 15 mg oral d-amphetamine also produced prototypical stimulant-like effects, but failed to alter break points for d-amphetamine on the modified progressive-ratio procedure relative to placebo pretreatment. These results indicate that acute d-amphetamine pretreatment does not increase stimulant self-administration.

Citing Articles

An Exploration of Responses to Drug Conditioned Stimuli during Treatment for Substance Dependence.

Goddard B, Hing L, Leri F J Addict. 2014; 2013:394064.

PMID: 24826360 PMC: 4007739. DOI: 10.1155/2013/394064.

Separate and combined impact of acute naltrexone and alprazolam on subjective and physiological effects of oral d-amphetamine in stimulant users.

Marks K, Lile J, Stoops W, Rush C Psychopharmacology (Berl). 2014; 231(14):2741-50.

PMID: 24464531 PMC: 4074228. DOI: 10.1007/s00213-014-3449-x.

Influence of aripiprazole pretreatment on the reinforcing effects of methamphetamine in humans.

Stoops W, Bennett J, Lile J, Sevak R, Rush C Prog Neuropsychopharmacol Biol Psychiatry. 2013; 47:111-7.

PMID: 23994622 PMC: 3825805. DOI: 10.1016/j.pnpbp.2013.08.007.

Relationship between oral D-amphetamine self-administration and ratings of subjective effects: do subjective-effects ratings correspond with a progressive-ratio measure of drug-taking behavior?.

Bolin B, Reynolds A, Stoops W, Rush C Behav Pharmacol. 2013; 24(5-6):533-42.

PMID: 23881044 PMC: 4012251. DOI: 10.1097/FBP.0b013e3283645047.

Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers.

Comer S, Mogali S, Saccone P, Askalsky P, Martinez D, Walker E Neuropsychopharmacology. 2013; 38(12):2427-38.

PMID: 23736314 PMC: 3799062. DOI: 10.1038/npp.2013.143.

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