Roles of CD147 on T Lymphocytes Activation and MMP-9 Secretion in Systemic Lupus Erythematosus

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2007 May 10

PMID 17488482

Citations 22

Authors

Gina Pistol

Cristiana Matache

Ana Calugaru

Crina Stavaru

Stefanita Tanaseanu

Ruxandra Ionescu

Sergiu Dumitrache

Maria Stefanescu

Affiliations

Soon will be listed here.

Abstract

The cellular and molecular mechanisms involved in many abnormalities described in Systemic Lupus Erythematosus (SLE) are still unclear. Some of these abnormalities referred to the hyperactivation of T lymphocytes and the enhanced secretion of MMP-9 by peripheral blood mononuclear cells (PBMCs). Therefore, in this paper we investigated the potential role of CD147 molecule in these abnormalities. Our results demonstrated that CD147 molecule is overexpressed on CD3+T lymphocytes from SLE patients when compared with CD3+T lymphocytes from healthy donors. Monoclonal anti-CD147 antibodies, MEM-M6/1 clone, were able to inhibit protein tyrosine phosphorylation only in CD3 x CD28 costimulated T lymphocytes from SLE patients. However, this monoclonal antibody was unable to inhibit the enhanced activity of MMP-9 secreted by SLE PBMCs.

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References

Hochberg M . Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997; 40(9):1725. DOI: 10.1002/art.1780400928. View

Kasinrerk W, Fiebiger E, Stefanova I, Baumruker T, Knapp W, Stockinger H . Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. J Immunol. 1992; 149(3):847-54. View

Zucker S, Hymowitz M, Rollo E, Mann R, CONNER C, Cao J . Tumorigenic potential of extracellular matrix metalloproteinase inducer. Am J Pathol. 2001; 158(6):1921-8. PMC: 1891983. DOI: 10.1016/S0002-9440(10)64660-3. View

Schmidt R, Bultmann A, Ungerer M, Joghetaei N, Bulbul O, Thieme S . Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction. Circulation. 2006; 113(6):834-41. DOI: 10.1161/CIRCULATIONAHA.105.568162. View

Vassilopoulos D, Kovacs B, Tsokos G . TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus. J Immunol. 1995; 155(4):2269-81. View

Kammer G, Perl A, Richardson B, Tsokos G . Abnormal T cell signal transduction in systemic lupus erythematosus. Arthritis Rheum. 2002; 46(5):1139-54. DOI: 10.1002/art.10192. View

Matache C, Stefanescu M, Onu A, Tanaseanu S, Matei I, Frade R . p56lck activity and expression in peripheral blood lymphocytes from patients with systemic lupus erythematosus. Autoimmunity. 1999; 29(2):111-20. DOI: 10.3109/08916939908995380. View

Zhu P, Lu N, Shi Z, Zhou J, Wu Z, Yang Y . CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes. Arthritis Res Ther. 2006; 8(2):R44. PMC: 1526600. DOI: 10.1186/ar1899. View

Nabeshima K, Suzumiya J, Nagano M, Ohshima K, Toole B, Tamura K . Emmprin, a cell surface inducer of matrix metalloproteinases (MMPs), is expressed in T-cell lymphomas. J Pathol. 2004; 202(3):341-51. DOI: 10.1002/path.1518. View

10.

DeCastro R, Zhang Y, Guo H, Kataoka H, GORDON M, Toole B . Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer. J Invest Dermatol. 1996; 106(6):1260-5. DOI: 10.1111/1523-1747.ep12348959. View

11.

Chiampanichayakul S, Peng-in P, Khunkaewla P, Stockinger H, Kasinrerk W . CD147 contains different bioactive epitopes involving the regulation of cell adhesion and lymphocyte activation. Immunobiology. 2006; 211(3):167-78. DOI: 10.1016/j.imbio.2005.08.007. View

12.

Nambiar M, Krishnan S, Warke V, Tsokos G . TCR zeta-chain abnormalities in human systemic lupus erythematosus. Methods Mol Med. 2004; 102:49-72. DOI: 10.1385/1-59259-805-6:049. View

13.

Miyauchi T, Masuzawa Y, Muramatsu T . The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. J Biochem. 1991; 110(5):770-4. DOI: 10.1093/oxfordjournals.jbchem.a123657. View

14.

Yurchenko V, Zybarth G, OConnor M, Dai W, Franchin G, Hao T . Active site residues of cyclophilin A are crucial for its signaling activity via CD147. J Biol Chem. 2002; 277(25):22959-65. DOI: 10.1074/jbc.M201593200. View

15.

Takeuchi T, Pang M, Amano K, Koide J, Abe T . Reduced protein tyrosine phosphatase (PTPase) activity of CD45 on peripheral blood lymphocytes in patients with systemic lupus erythematosus (SLE). Clin Exp Immunol. 1997; 109(1):20-6. PMC: 1904709. DOI: 10.1046/j.1365-2249.1997.4371334.x. View

16.

Gabison E, Hoang-Xuan T, Mauviel A, Menashi S . EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. Biochimie. 2005; 87(3-4):361-8. DOI: 10.1016/j.biochi.2004.09.023. View

17.

Yang J, ONeill P, Jin W, Foty R, Medina D, Xu Z . Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem. 2006; 281(14):9719-27. DOI: 10.1074/jbc.M508421200. View

18.

Renno T, Wilson A, Dunkel C, Coste I, Maisnier-Patin K, de Coignac A . A role for CD147 in thymic development. J Immunol. 2002; 168(10):4946-50. DOI: 10.4049/jimmunol.168.10.4946. View

19.

Jury E, Kabouridis P, Flores-Borja F, Mageed R, Isenberg D . Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. J Clin Invest. 2004; 113(8):1176-87. PMC: 385405. DOI: 10.1172/JCI20345. View

20.

Fossum S, Mallett S, Barclay A . The MRC OX-47 antigen is a member of the immunoglobulin superfamily with an unusual transmembrane sequence. Eur J Immunol. 1991; 21(3):671-9. DOI: 10.1002/eji.1830210320. View