Th17 Cells in Inflammatory Conditions

Overview

Journal Rev Diabet Stud

Specialty Endocrinology

Date 2007 May 10

PMID 17487329

Citations 27

Authors

Anne Cooke

Affiliations

Soon will be listed here.

Abstract

CD4(+) T cells have been subdivided into different subsets, largely on the basis of the cytokines they produce. These subsets include Th1, Th2 and regulatory T cells. Recently, another population of T cells have been described, namely Th17, which are characterized by their production of IL-17. Two other important cytokines, which are related to each other, are associated with the development of Th cells, namely IL-12 and IL-23. While IL-12 plays a key role in the differentiation of naïve T cells to Th1 cells, IL-23 promotes the expansion of Th17 cells. IL-12 and IL-23 are heterodimers with a shared subunit, p40. They furthermore bind to receptors which have unique and shared subunits. Several previous studies have evaluated the role of IL-12 in inflammatory diseases on the basis of p40. Therefore a reevaluation of the role of IL-12 and Th1 cells in a range of inflammatory conditions has been carried out. This new wave of studies has resulted in the recognition of the role of IL-23 and Th17 cells in inflammatory conditions, such as arthritis and inflammatory bowel disease. There is also the speculation about a possible role in type 1 diabetes.

Citing Articles

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