Impact of Anxiety and Depression on Functional Impairment in Adolescents with Asthma

Overview

Journal Gen Hosp Psychiatry

Specialties Health Services
Psychiatry

Date 2007 May 9

PMID 17484938

Citations 36

Authors

Elizabeth McCauley

Wayne Katon

Joan Russo

Laura Richardson

Paula Lozano

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to assess the association of anxiety and depression with psychosocial and asthma-related functional impairment in a large-population-based sample of adolescents with asthma.

Method: The sample consisted of 767 youths ages 11 to 17 with a documented diagnosis of, and active treatment for, asthma. Telephone interviews were completed with each youth and one parent to assess asthma-related symptoms and self-report of psychosocial and asthma-related functional status. Structured diagnostic interviews (Computerized Diagnostic Interview Schedule for Children) were administered to determine psychiatric diagnoses. Weighted multiple linear regression models were employed to identify variables that were independently and significantly associated with levels of functioning.

Results: One hundred twenty-five youths (16.2%) met DSM-IV criteria for one or more anxiety and depressive disorders in the last 12 months. After controlling for demographic variables, greater severity of self-reported depressive and anxiety symptoms and presence of one or more DSM-IV anxiety or depressive diagnosis were associated with psychosocial and asthma-related functional status. The mental health factors were more strongly associated with measures of asthma and psychological functional outcomes than the modified Health Plan Employer Data and Information Set asthma risk measure.

Conclusions: Increased awareness of the need to assess and effectively treat psychiatric symptoms in youth with asthma may reduce the functional burden associated with asthma.

Citing Articles

Social determinants of mental health in asthma: an exploratory study.

Hiles S, Lewthwaite H, Clark V, Vertigan A, Smith A, McDonald V Front Allergy. 2025; 5:1464948.

PMID: 39973940 PMC: 11835874. DOI: 10.3389/falgy.2024.1464948.

The prevalence of multiple chronic conditions and medical burden in asthma patients.

Jo E, Lee Y, Kim A, Park H, Kim C PLoS One. 2023; 18(5):e0286004.

PMID: 37200347 PMC: 10194904. DOI: 10.1371/journal.pone.0286004.

Symptoms of anxiety and depression in patients with persistent asthma: a cross-sectional analysis of the INSPIRERS studies.

Simoes Cunha M, Amaral R, Pereira A, Almeida R, Alves-Correia M, Loureiro C BMJ Open. 2023; 13(5):e068725.

PMID: 37147092 PMC: 10163458. DOI: 10.1136/bmjopen-2022-068725.

Associations of asthma self-management and mental health in adolescents: A scoping review.

Leonard S, Turi E, Powell J, Usseglio J, MacDonell K, Bruzzese J Respir Med. 2022; 200:106897.

PMID: 35714575 PMC: 9871877. DOI: 10.1016/j.rmed.2022.106897.

Longitudinal Relationships Between Depression and Chronic Illness in Adolescents: An Integrative Review.

Zheng K, Abraham C, Bruzzese J, Smaldone A J Pediatr Health Care. 2020; 34(4):333-345.

PMID: 32171610 PMC: 7313149. DOI: 10.1016/j.pedhc.2020.01.008.

References

Zaubler T, Katon W . Panic disorder and medical comorbidity: a review of the medical and psychiatric literature. Bull Menninger Clin. 1996; 60(2 Suppl A):A12-38. View

Greineder D, Loane K, Parks P . Reduction in resource utilization by an asthma outreach program. Arch Pediatr Adolesc Med. 1995; 149(4):415-20. DOI: 10.1001/archpedi.1995.02170160069010. View

Roy-Byrne P, Stein M . Inspiring panic. Arch Gen Psychiatry. 2001; 58(2):123-4. DOI: 10.1001/archpsyc.58.2.123. View

Sullivan M, LaCroix A, Baum C, Grothaus L, Katon W . Functional status in coronary artery disease: a one-year prospective study of the role of anxiety and depression. Am J Med. 1997; 103(5):348-56. DOI: 10.1016/s0002-9343(97)00167-8. View

Wells K, Burnam M, Leake B, ROBINS L . Agreement between face-to-face and telephone-administered versions of the depression section of the NIMH Diagnostic Interview Schedule. J Psychiatr Res. 1988; 22(3):207-20. DOI: 10.1016/0022-3956(88)90006-4. View

Weil C, Wade S, Bauman L, Lynn H, Mitchell H, Lavigne J . The relationship between psychosocial factors and asthma morbidity in inner-city children with asthma. Pediatrics. 1999; 104(6):1274-80. DOI: 10.1542/peds.104.6.1274. View

Kean E, Kelsay K, Wamboldt F, Wamboldt M . Posttraumatic stress in adolescents with asthma and their parents. J Am Acad Child Adolesc Psychiatry. 2005; 45(1):78-86. DOI: 10.1097/01.chi.0000186400.67346.02. View

Shaffer D, Fisher P, Lucas C, Dulcan M . NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry. 2000; 39(1):28-38. DOI: 10.1097/00004583-200001000-00014. View

Asmussen L, Olson L, Grant E, Fagan J, Weiss K . Reliability and validity of the Children's Health Survey for Asthma. Pediatrics. 1999; 104(6):e71. DOI: 10.1542/peds.104.6.e71. View

10.

Horowitz J, Garber J . The prevention of depressive symptoms in children and adolescents: A meta-analytic review. J Consult Clin Psychol. 2006; 74(3):401-15. DOI: 10.1037/0022-006X.74.3.401. View

11.

Wells K, Golding J, Burnam M . Psychiatric disorder in a sample of the general population with and without chronic medical conditions. Am J Psychiatry. 1988; 145(8):976-81. DOI: 10.1176/ajp.145.8.976. View

12.

Richardson L, Lozano P, Russo J, McCauley E, Bush T, Katon W . Asthma symptom burden: relationship to asthma severity and anxiety and depression symptoms. Pediatrics. 2006; 118(3):1042-51. DOI: 10.1542/peds.2006-0249. View

13.

Vila G, Nollet-Clemencon C, de Blic J, Mouren-Simeoni M, Scheinmann P . Prevalence of DSM IV anxiety and affective disorders in a pediatric population of asthmatic children and adolescents. J Affect Disord. 2000; 58(3):223-31. DOI: 10.1016/s0165-0327(99)00110-x. View

14.

Goodwin R, Fergusson D, Horwood L . Asthma and depressive and anxiety disorders among young persons in the community. Psychol Med. 2005; 34(8):1465-74. DOI: 10.1017/s0033291704002739. View

15.

McQuaid E, Kopel S, Nassau J . Behavioral adjustment in children with asthma: a meta-analysis. J Dev Behav Pediatr. 2002; 22(6):430-9. DOI: 10.1097/00004703-200112000-00011. View

16.

Fishman P, Shay D . Development and estimation of a pediatric chronic disease score using automated pharmacy data. Med Care. 1999; 37(9):874-83. DOI: 10.1097/00005650-199909000-00004. View

17.

Mrazek D . Psychiatric symptoms in patients with asthma causality, comorbidity, or shared genetic etiology. Child Adolesc Psychiatr Clin N Am. 2003; 12(3):459-71. DOI: 10.1016/s1056-4993(03)00028-2. View

18.

Silverman W, Ginsburg G, Goedhart A . Factor structure of the childhood anxiety sensitivity index. Behav Res Ther. 1999; 37(9):903-17. DOI: 10.1016/s0005-7967(98)00189-2. View

19.

Weiss K, Gergen P, Wagener D . Breathing better or wheezing worse? The changing epidemiology of asthma morbidity and mortality. Annu Rev Public Health. 1993; 14:491-513. DOI: 10.1146/annurev.pu.14.050193.002423. View

20.

Nystad W, Magnus P, Gulsvik A, Skarpaas I, Carlsen K . Changing prevalence of asthma in school children: evidence for diagnostic changes in asthma in two surveys 13 yrs apart. Eur Respir J. 1997; 10(5):1046-51. DOI: 10.1183/09031936.97.10051046. View