Morphological Alteration of Gut-associated Lymphoid Tissue After Long-term Total Parenteral Nutrition in Rats

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 1991 Oct 1

PMID 1747912

Citations 7

Authors

S Tanaka

S Miura

H Tashiro

H Serizawa

Y Hamada

M Yoshioka

M Tsuchiya

Affiliations

Soon will be listed here.

Abstract

The morphological alteration of gut-associated lymphoid tissue (GALT) induced by long-term absence of dietary stimulation was investigated. Male Wistar rats weighing approximately 230 g were maintained with total parenteral nutrition (TPN). Control rats were allowed to have the same amount of the solution orally. After two weeks, the morphological alteration of GALT was examined. Although no significant difference in weight gain was noted between the two groups, the area comprised by Peyer's patches was decreased in TPN rats. The number of transported lymphocytes and the ratio of helper T (Th) cells to suppressor/cytotoxic T (Ts/c) cells in intestinal lymph were lowered after TPN treatment. In an immunohistochemical study of the rat ileum, the number of T cells and the Th/Ts/c ratio were decreased both in the intraepithelial spaces and in the lamina propria of TPN rats. The percentage of interleukin-2 receptor-positive cells and the number of IgA-containing cells in the lamina propria were significantly reduced in TPN rats. These results suggest that dietary stimulation might play a role in the maintenance of GALT function and morphology.

Citing Articles

Total parenteral nutrition causes circumferential intestinal atrophy, remodeling of the intestinal wall, and redistribution of eosinophils in the rat gastrointestinal tract.

Ekelund M, Kristensson E, Ekelund M, Ekblad E Dig Dis Sci. 2007; 52(8):1833-9.

PMID: 17390221 DOI: 10.1007/s10620-006-9678-z.

The effects of proteoglycan on GALT in rats treated with TPN.

Nakasaki H, Kamijho A, Mitomi T, Tajima T, Fujii K Surg Today. 1997; 27(10):941-5.

PMID: 10870581 DOI: 10.1007/BF02388143.

Recovery of gut-associated lymphoid tissue and upper respiratory tract immunity after parenteral nutrition.

Janu P, Li J, Renegar K, Kudsk K Ann Surg. 1997; 225(6):707-15; discussion 715-7.

PMID: 9230811 PMC: 1190874. DOI: 10.1097/00000658-199706000-00008.

Amelioration of chronic inflammation by ingestion of elemental diet in a rat model of granulomatous enteritis.

Tanaka S, Miura S, Kimura H, Ohkubo N, Tsuzuki Y, Fukumura D Dig Dis Sci. 1997; 42(2):408-19.

PMID: 9052527 DOI: 10.1023/a:1018890624384.

Loss of upper respiratory tract immunity with parenteral feeding.

Kudsk K, Li J, Renegar K Ann Surg. 1996; 223(6):629-35; discussion 635-8.

PMID: 8645036 PMC: 1235201. DOI: 10.1097/00000658-199606000-00001.

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