AMPK Mediates Autophagy During Myocardial Ischemia in Vivo

Overview

Journal Autophagy

Specialty Cell Biology

Date 2007 May 2

PMID 17471015

Citations 78

Authors

Hiromitsu Takagi

Yutaka Matsui

Shinichi Hirotani

Hideyuki Sakoda

Tomoichiro Asano

Junichi Sadoshima

Affiliations

Soon will be listed here.

Abstract

We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.

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