Mycoplasma Genitalium Among Adolescent Women and Their Partners

Overview

Journal J Adolesc Health

Publisher Elsevier

Specialty Pediatrics

Date 2007 Apr 24

PMID 17448398

Citations 32

Authors

Aneesh K Tosh

Barbara Van Der Pol

J Dennis Fortenberry

James A Williams

Barry P Katz

Byron E Batteiger

Donald P Orr

Affiliations

Soon will be listed here.

Abstract

Purpose: Mycoplasma genitalium is a possible sexually transmitted pathogen and its study among the adolescent age group has been limited. In this longitudinal study, the epidemiology, natural history, and associated clinical findings of M. genitalium among adolescents in a primary care setting were explored.

Methods: A sample of 383 young women (14-17 years of age) and 117 male partners provided sexual behavior data and urogenital samples for polymerase chain reaction testing to detect M. genitalium, Chlamydia trachomatis, and other sexually transmitted infections. Women were tested quarterly for up to 27 months and, during every other quarter, tested weekly. The presence of any signs or symptoms of infection among the female subjects was also documented.

Results: Cumulatively, 13.6% (52/383) of women tested positive for M. genitalium. All women with M. genitalium, except one, were sexually experienced. M. genitalium was associated with number of sexual partners (p < .001) and C. trachomatis infection (p < .03). M. genitalium was more likely among male partners of M. genitalium-positive women (p < .02); 31.3% of untreated M. genitalium cases had infection lasting over 8 weeks. M. genitalium was not associated with the presence of clinical signs or symptoms of infection.

Conclusions: Findings support sexual transmissibility of M. genitalium and add to understanding of M. genitalium natural history and clinical findings.

Citing Articles

Features Associated With Mycoplasma genitalium Infection.

Sheele J, Bragg K Cureus. 2024; 16(10):e72728.

PMID: 39618602 PMC: 11606620. DOI: 10.7759/cureus.72728.

Sexually Transmitted Infections in Adolescents and Young Adults: A Cross Section of Public Health.

Cannovo N, Bianchini E, Gironacci L, Garbati E, Di Prospero F, Cingolani M Int J Environ Res Public Health. 2024; 21(4).

PMID: 38673412 PMC: 11050350. DOI: 10.3390/ijerph21040501.

Mycoplasma genitalium in Singapore is associated with Chlamydia trachomatis infection and displays high macrolide and Fluoroquinolone resistance rates.

Hart T, Tang W, Mansoor S, Chio M, Barkham T BMC Infect Dis. 2020; 20(1):314.

PMID: 32345231 PMC: 7189604. DOI: 10.1186/s12879-020-05019-1.

Mycoplasma genitalium Coinfection in Women With Chlamydia trachomatis Infection.

Harrison S, Olson K, Ratliff A, Xiao L, Van Der Pol B, Waites K Sex Transm Dis. 2019; 46(10):e101-e104.

PMID: 31517808 PMC: 7457732. DOI: 10.1097/OLQ.0000000000001028.

incidence, persistence, concordance between partners and progression: systematic review and meta-analysis.

Cina M, Baumann L, Egli-Gany D, Halbeisen F, Ali H, Scott P Sex Transm Infect. 2019; 95(5):328-335.

PMID: 31055469 PMC: 6678058. DOI: 10.1136/sextrans-2018-053823.

References

Van Der Pol B, Quinn T, Gaydos C, Crotchfelt K, Schachter J, Moncada J . Multicenter evaluation of the AMPLICOR and automated COBAS AMPLICOR CT/NG tests for detection of Chlamydia trachomatis. J Clin Microbiol. 2000; 38(3):1105-12. PMC: 86350. DOI: 10.1128/JCM.38.3.1105-1112.2000. View

Wroblewski J, Manhart L, Dickey K, Hudspeth M, Totten P . Comparison of transcription-mediated amplification and PCR assay results for various genital specimen types for detection of Mycoplasma genitalium. J Clin Microbiol. 2006; 44(9):3306-12. PMC: 1594725. DOI: 10.1128/JCM.00553-06. View

Keane F, Thomas B, Gilroy C, Renton A, Taylor-Robinson D . The association of Chlamydia trachomatis and Mycoplasma genitalium with non-gonococcal urethritis: observations on heterosexual men and their female partners. Int J STD AIDS. 2000; 11(7):435-9. DOI: 10.1258/0956462001916209. View

Martin D, Cammarata C, Van Der Pol B, Jones R, Quinn T, Gaydos C . Multicenter evaluation of AMPLICOR and automated COBAS AMPLICOR CT/NG tests for Neisseria gonorrhoeae. J Clin Microbiol. 2000; 38(10):3544-9. PMC: 87434. DOI: 10.1128/JCM.38.10.3544-3549.2000. View

Totten P, Schwartz M, SJOSTROM K, KENNY G, Handsfield H, Weiss J . Association of Mycoplasma genitalium with nongonococcal urethritis in heterosexual men. J Infect Dis. 2000; 183(2):269-276. DOI: 10.1086/317942. View

Mena L, Wang X, Mroczkowski T, Martin D . Mycoplasma genitalium infections in asymptomatic men and men with urethritis attending a sexually transmitted diseases clinic in New Orleans. Clin Infect Dis. 2002; 35(10):1167-73. DOI: 10.1086/343829. View

Manhart L, Critchlow C, Holmes K, Dutro S, Eschenbach D, Stevens C . Mucopurulent cervicitis and Mycoplasma genitalium. J Infect Dis. 2003; 187(4):650-7. DOI: 10.1086/367992. View

Simms I, Eastick K, Mallinson H, Thomas K, Gokhale R, Hay P . Associations between Mycoplasma genitalium, Chlamydia trachomatis, and pelvic inflammatory disease. Sex Transm Infect. 2003; 79(2):154-6. PMC: 1744630. DOI: 10.1136/sti.79.2.154. View

Dutro S, Hebb J, Garin C, Hughes J, Kenny G, Totten P . Development and performance of a microwell-plate-based polymerase chain reaction assay for Mycoplasma genitalium. Sex Transm Dis. 2003; 30(10):756-63. DOI: 10.1097/01.OLQ.0000078821.27933.88. View

10.

Baseman J, Cagle M, Korte J, Herrera C, Rasmussen W, Baseman J . Diagnostic assessment of Mycoplasma genitalium in culture-positive women. J Clin Microbiol. 2004; 42(1):203-11. PMC: 321719. DOI: 10.1128/JCM.42.1.203-211.2004. View

11.

Tully J, Taylor-Robinson D, Cole R, ROSE D . A newly discovered mycoplasma in the human urogenital tract. Lancet. 1981; 1(8233):1288-91. DOI: 10.1016/s0140-6736(81)92461-2. View

12.

Jensen J, Uldum S, Vuust J, Lind K . Polymerase chain reaction for detection of Mycoplasma genitalium in clinical samples. J Clin Microbiol. 1991; 29(1):46-50. PMC: 269700. DOI: 10.1128/jcm.29.1.46-50.1991. View

13.

Palmer H, Gilroy C, Furr P, Taylor-Robinson D . Development and evaluation of the polymerase chain reaction to detect Mycoplasma genitalium. FEMS Microbiol Lett. 1991; 61(2-3):199-203. DOI: 10.1016/0378-1097(91)90551-k. View

14.

Horner P, Gilroy C, Thomas B, Naidoo R, Taylor-Robinson D . Association of Mycoplasma genitalium with acute non-gonococcal urethritis. Lancet. 1993; 342(8871):582-5. DOI: 10.1016/0140-6736(93)91411-e. View

15.

Blanchard A, Hamrick W, Duffy L, Baldus K, Cassell G . Use of the polymerase chain reaction for detection of Mycoplasma fermentans and Mycoplasma genitalium in the urogenital tract and amniotic fluid. Clin Infect Dis. 1993; 17 Suppl 1:S272-9. DOI: 10.1093/clinids/17.supplement_1.s272. View

16.

Fraser C, Gocayne J, White O, Adams M, Clayton R, Fleischmann R . The minimal gene complement of Mycoplasma genitalium. Science. 1995; 270(5235):397-403. DOI: 10.1126/science.270.5235.397. View

17.

Falk L, Fredlund H, Jensen J . Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection. Sex Transm Infect. 2005; 81(1):73-8. PMC: 1763725. DOI: 10.1136/sti.2004.010439. View

18.

Anagrius C, Lore B, Jensen J . Mycoplasma genitalium: prevalence, clinical significance, and transmission. Sex Transm Infect. 2005; 81(6):458-62. PMC: 1745067. DOI: 10.1136/sti.2004.012062. View

19.

Van Der Pol B, Kraft C, Williams J . Use of an adaptation of a commercially available PCR assay aimed at diagnosis of chlamydia and gonorrhea to detect Trichomonas vaginalis in urogenital specimens. J Clin Microbiol. 2006; 44(2):366-73. PMC: 1392661. DOI: 10.1128/JCM.44.2.366-373.2006. View

20.

Korte J, Baseman J, Cagle M, Herrera C, Piper J, Holden A . Cervicitis and genitourinary symptoms in women culture positive for Mycoplasma genitalium. Am J Reprod Immunol. 2006; 55(4):265-75. DOI: 10.1111/j.1600-0897.2005.00359.x. View