Inflammatory Mechanisms and Remodeling in Chronic Rhinosinusitis and Nasal Polyps

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2007 Apr 24

PMID 17448332

Citations 44

Authors

Ruby Pawankar

Manabu Nonaka

Affiliations

Soon will be listed here.

Abstract

Chronic rhinosinusitis (CRS) is presently classified into two subgroups: CRS without and CRS with nasal polyps. A variety of inflammatory mediators, including cytokines and chemokines, as well as adhesion molecules and matrix metalloproteinases, are upregulated in both subgroups of CRS; remodeling is also observed in both. However, there are also characteristic differences. Whereas CRS without nasal polyps has more neutrophilic infiltration, in CRS with nasal polyps (especially when associated with allergy/asthma) eosinophil infiltration is strikingly increased. Although several features of remodeling (eg, squamous metaplasia, basement membrane thickening, collagen deposition, hyperplasia of mucous glands, and goblet cells) are features seen in both subgroups of CRS, epithelial shedding as observed in asthma is not seen in either subgroup. Furthermore, pseudocyst formation seen in CRS with nasal polyps is not seen in CRS without nasal polyps.

Citing Articles

Evaluation of CNPase and TGFβ1/Smad Signalling Pathway Molecule Expression in Sinus Epithelial Tissues of Patients with Chronic Rhinosinusitis with (CRSwNP) and without Nasal Polyps (CRSsNP).

Piszczatowska K, Czerwaty K, Dzaman K, Jermakow N, Brzost J, Kantor I J Pers Med. 2024; 14(9).

PMID: 39338148 PMC: 11433593. DOI: 10.3390/jpm14090894.

Inhibitory effect of doxycycline conjugated with deoxycholic acid and polyethylenimine conjugate on nasal fibroblast differentiation and extracellular production.

Shin J, Yang H, Lim S, Jeong J, Park I PLoS One. 2024; 19(5):e0285655.

PMID: 38753593 PMC: 11098436. DOI: 10.1371/journal.pone.0285655.

Pediatric chronic rhinosinusitis.

Ramadan H Eur Arch Otorhinolaryngol. 2023; 281(3):1131-1137.

PMID: 37899371 DOI: 10.1007/s00405-023-08307-z.

The interplay of inflammation and remodeling in the pathogenesis of chronic rhinosinusitis: current understanding and future directions.

Gong X, Han Z, Fan H, Wu Y, He Y, Fu Y Front Immunol. 2023; 14:1238673.

PMID: 37771597 PMC: 10523020. DOI: 10.3389/fimmu.2023.1238673.

Unraveling the Role of Epithelial Cells in the Development of Chronic Rhinosinusitis.

Ha J, Cho H Int J Mol Sci. 2023; 24(18).

PMID: 37762530 PMC: 10531804. DOI: 10.3390/ijms241814229.

References

Hamilos D, Leung D, Huston D, Kamil A, Wood R, Hamid Q . GM-CSF, IL-5 and RANTES immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis (NP). Clin Exp Allergy. 1998; 28(9):1145-52. DOI: 10.1046/j.1365-2222.1998.00380.x. View

Stierna P, Carlsoo B . Histopathological observations in chronic maxillary sinusitis. Acta Otolaryngol. 1990; 110(5-6):450-8. DOI: 10.3109/00016489009107468. View

Bolger W, Leonard D, Dick Jr E, Stierna P . Gram negative sinusitis: a bacteriologic and histologic study in rabbits. Am J Rhinol. 1997; 11(1):15-25. DOI: 10.2500/105065897781446766. View

Pawankar R . Nasal polyposis: an update: editorial review. Curr Opin Allergy Clin Immunol. 2003; 3(1):1-6. DOI: 10.1097/00130832-200302000-00001. View

Mempel M, Lina G, Hojka M, Schnopp C, Seidl H, Schafer T . High prevalence of superantigens associated with the egc locus in Staphylococcus aureus isolates from patients with atopic eczema. Eur J Clin Microbiol Infect Dis. 2003; 22(5):306-9. DOI: 10.1007/s10096-003-0928-0. View

McCormick J, Yarwood J, Schlievert P . Toxic shock syndrome and bacterial superantigens: an update. Annu Rev Microbiol. 2001; 55:77-104. DOI: 10.1146/annurev.micro.55.1.77. View

Suzuki H, Takahashi Y, Wataya H, Ikeda K, Nakabayashi S, Shimomura A . Mechanism of neutrophil recruitment induced by IL-8 in chronic sinusitis. J Allergy Clin Immunol. 1996; 98(3):659-70. DOI: 10.1016/s0091-6749(96)70100-8. View

Holt P, Sly P . Interactions between respiratory tract infections and atopy in the aetiology of asthma. Eur Respir J. 2002; 19(3):538-45. DOI: 10.1183/09031936.02.00229302. View

Hamilos D, Leung D, Wood R, Cunningham L, Bean D, Yasruel Z . Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis. J Allergy Clin Immunol. 1995; 96(4):537-44. DOI: 10.1016/s0091-6749(95)70298-9. View

10.

Kirtsreesakul V, Naclerio R . Role of allergy in rhinosinusitis. Curr Opin Allergy Clin Immunol. 2004; 4(1):17-23. DOI: 10.1097/00130832-200402000-00005. View

11.

Min Y, Lee C, Rhee C, Hong S, Kwon S . Increased expression of IL-4, IL-5, IFN-gamma, IL-6, IL-8, and TGF-beta mRNAs in maxillary mucosa of patients with chronic sinusitis. Am J Rhinol. 1999; 13(5):339-43. DOI: 10.2500/105065899781367546. View

12.

Ishibashi T, Tanaka T, Nibu K, Ishimoto S, Kaga K . Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps. Ann Otol Rhinol Laryngol. 1998; 107(10 Pt 1):885-90. DOI: 10.1177/000348949810701013. View

13.

Llewelyn M, Cohen J . Superantigens: microbial agents that corrupt immunity. Lancet Infect Dis. 2002; 2(3):156-62. DOI: 10.1016/s1473-3099(02)00222-0. View

14.

Van Cauwenberge P, Ingels K . Effects of viral and bacterial infection on nasal and sinus mucosa. Acta Otolaryngol. 1996; 116(2):316-21. DOI: 10.3109/00016489609137849. View

15.

Van Zele T, Gevaert P, Watelet J, Claeys G, Holtappels G, Claeys C . Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. J Allergy Clin Immunol. 2004; 114(4):981-3. DOI: 10.1016/j.jaci.2004.07.013. View

16.

Ponikau J, Sherris D, Kephart G, Kern E, Gaffey T, Tarara J . Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma?. J Allergy Clin Immunol. 2003; 112(5):877-82. DOI: 10.1016/j.jaci.2003.08.009. View

17.

Tokushige E, Itoh K, Ushikai M, Katahira S, Fukuda K . Localization of IL-1 beta mRNA and cell adhesion molecules in the maxillary sinus mucosa of patients with chronic sinusitis. Laryngoscope. 1994; 104(10):1245-50. DOI: 10.1288/00005537-199410000-00011. View

18.

Montefort S, Roberts J, Beasley R, Holgate S, Roche W . The site of disruption of the bronchial epithelium in asthmatic and non-asthmatic subjects. Thorax. 1992; 47(7):499-503. PMC: 463857. DOI: 10.1136/thx.47.7.499. View

19.

Khalid A, Hunt J, Perloff J, Kennedy D . The role of bone in chronic rhinosinusitis. Laryngoscope. 2002; 112(11):1951-7. DOI: 10.1097/00005537-200211000-00008. View

20.

Belleguic C, Corbel M, Germain N, Lena H, Boichot E, Delaval P . Increased release of matrix metalloproteinase-9 in the plasma of acute severe asthmatic patients. Clin Exp Allergy. 2002; 32(2):217-23. DOI: 10.1046/j.1365-2222.2002.01219.x. View