Apoptosis and Chemo-resistance in Colorectal Cancer

Overview

Journal J Surg Oncol

Specialties General Surgery
Oncology

Date 2007 Apr 20

PMID 17443738

Citations 12

Authors

S G Prabhudesai

S Rekhraj

G Roberts

A W Darzi

P Ziprin

Affiliations

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Abstract

Systemic chemotherapy plays an integral part in treating advanced colorectal cancer. However 50% of patients respond poorly or have disease progression due to resistance to chemotherapeutic agents. This article reviews the pathways that regulate apoptosis, apoptotic mechanisms through which chemotherapeutic agents mediate their effect and how deregulation of apoptotic proteins may contribute to chemo-resistance. Also discussed are potential therapeutic strategies designed to target these proteins and thereby improve response rates to chemotherapy in colorectal cancer.

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